Asthma exacerbations: pathogenesis, prevention, and treatment

JR Castillo, SP Peters, WW Busse - The Journal of Allergy and Clinical …, 2017 - Elsevier
Guideline-based management of asthma focuses on disease severity and choosing the
appropriate medical therapy to control symptoms and reduce the risk of exacerbations …

Treatment strategies for asthma: reshaping the concept of asthma management

A Papi, F Blasi, GW Canonica, L Morandi… - Allergy, Asthma & …, 2020 - Springer
Asthma is a common chronic disease characterized by episodic or persistent respiratory
symptoms and airflow limitation. Asthma treatment is based on a stepwise and control-based …

GINA 2019: a fundamental change in asthma management: treatment of asthma with short-acting bronchodilators alone is no longer recommended for adults and …

HK Reddel, JM FitzGerald, ED Bateman… - European …, 2019 - Eur Respiratory Soc
GINA no longer recommends treating adults/adolescents with asthma with short-acting
bronchodilators alone. Instead, they should receive symptom-driven (in mild asthma) or a …

Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52 …

J Hardy, C Baggott, J Fingleton, HK Reddel, RJ Hancox… - The Lancet, 2019 - thelancet.com
Background In adults with mild asthma, a combination of an inhaled corticosteroid with a fast-
onset long-acting β-agonist (LABA) used as reliever monotherapy reduces severe …

An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials …

HK Reddel, DR Taylor, ED Bateman… - American journal of …, 2009 - atsjournals.org
Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …

The frequency of asthma exacerbations and healthcare utilization in patients with asthma from the UK and USA

RY Suruki, JB Daugherty, N Boudiaf… - BMC pulmonary …, 2017 - Springer
Background Asthma exacerbations are frequent in patients with severe disease. This report
describes results from two retrospective cohort studies describing exacerbation frequency …

Global strategy for asthma management and prevention: GINA executive summary

ED Bateman, SS Hurd, PJ Barnes… - European …, 2008 - Eur Respiratory Soc
Asthma is a serious health problem throughout the world. During the past two decades,
many scientific advances have improved our understanding of asthma and ability to manage …

Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study

ED Bateman, HA Boushey, J Bousquet… - American journal of …, 2004 - atsjournals.org
For most patients, asthma is not controlled as defined by guidelines; whether this is
achievable has not been prospectively studied. A 1-year, randomized, stratified, double …

[HTML][HTML] Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

M Mehta, DS Dhanjal, KR Paudel, B Singh… - …, 2020 - Springer
Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …

Asthma-Related Health Outcomes Associated with Short-Acting β2-Agonist Inhaler Use: An Observational UK Study as Part of the SABINA Global Program

CI Bloom, C Cabrera, S Arnetorp, K Coulton, C Nan… - Advances in …, 2020 - Springer
Introduction Patients with asthma typically increase short-acting β 2-agonists (SABA) use
with worsening symptoms. Excessive SABA use may lead to a higher risk of adverse …