During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …

In the two decades since the introduction of the “click chemistry” concept, the toolbox of “click
reactions” has continually expanded, enabling chemists, materials scientists, and biologists …

The liquid–liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) is a
commonly observed phenomenon within the cell, and such condensates are also highly …

Genetic elements compete for transmission through meiosis, when haploid gametes are
created from a diploid parent. Selfish elements can enhance their transmission through a …

Telomerase-free cancer cells employ a recombination-based alternative lengthening of
telomeres (ALT) pathway that depends on ALT-associated promyelocytic leukemia nuclear …

Visualizing and manipulating the behavior of proteins is crucial to understanding the
physiology of the cell. Methods of biorthogonal protein labeling are important tools to attain …

During metaphase, chromosome position at the spindle equator is regulated by the forces
exerted by kinetochore microtubules and polar ejection forces. However, the role of forces …

Chemically induced proximity (CIP) is a powerful tool to study cellular functions. However
with current CIP inducers it is difficult to directly modulate unligandable and endogenous …

Proteolysis targeting chimeras (PROTAC) represents a new type of small molecule induced
protein degradation technology that has emerged in recent years. PROTAC uses …

Light‐inducible approaches provide a means to control biological systems with spatial and
temporal resolution that is unmatched by traditional genetic perturbations. Recent …