Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Organisms of all domains of life use photoreceptor proteins to sense and respond to light.
The light-sensitivity of photoreceptor proteins arises from bound chromophores such as …

The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …

In response to adenosine 5′-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet
aggregation, and thus serves as an important antithrombotic drug target. Here we report the …

How drugs bind to their receptors—from initial association, through drug entry into the
binding pocket, to adoption of the final bound conformation, or “pose”—has remained …

The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking,
endothelial development and integrity, heart rate, and vascular tone and maturation by …

Abstract Human GPR40 receptor (hGPR40), also known as free fatty-acid receptor 1
(FFAR1), is a G-protein-coupled receptor that binds long-chain free fatty acids to enhance …

G-protein-coupled receptors (GPCRs) are seven transmembrane helix (TM) proteins that
transduce signals into living cells by binding extracellular ligands and coupling to …

As succinctly summarized by Wolf, 1 lack of vitamin A (all-trans-retinol) was recognized by
ancient Egyptians as causing a visual deficiency involving the retina and cornea that could …

G-protein-coupled receptors (GPCRs) are involved in numerous physiological processes
and are the most frequent targets of approved drugs. The explosion in the number of new …