Synthesis of chalcones derivatives and their biological activities: a review
NAA Elkanzi, H Hrichi, RA Alolayan, W Derafa… - ACS …, 2022 - ACS Publications
Chalcone derivatives are considered valuable species because they possess a
ketoethylenic moiety, CO–CH═ CH–. Due to the presence of a reactive α, β-unsaturated …
ketoethylenic moiety, CO–CH═ CH–. Due to the presence of a reactive α, β-unsaturated …
Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line
FE Bennani, L Doudach, Y Cherrah, Y Ramli… - Bioorganic …, 2020 - Elsevier
Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C 3
H 3 N 2 H. The presence of this nucleus in pharmacological agents of various therapeutic …
H 3 N 2 H. The presence of this nucleus in pharmacological agents of various therapeutic …
Pyrimidine and fused pyrimidine derivatives as promising protein kinase inhibitors for cancer treatment
KRA Abdellatif, RB Bakr - Medicinal Chemistry Research, 2021 - Springer
Pyrimidine ring and its fused derivatives including pyrazolo [3, 4-d] pyrimidine, pyrido [2, 3-d]
pyrimidine, quinazoline, and furo [2, 3-d] pyrimidine compounds had received much interest …
pyrimidine, quinazoline, and furo [2, 3-d] pyrimidine compounds had received much interest …
Design, synthesis and biological evaluation of some novel benzothiazole/benzoxazole and/or benzimidazole derivatives incorporating a pyrazole scaffold as …
In an aim at developing new antiproliferative agents, new series of benzothiazole/
benzoxazole and/or benzimidazole substituted pyrazole derivatives 11a-c, 12a-c and 13a-c …
benzoxazole and/or benzimidazole substituted pyrazole derivatives 11a-c, 12a-c and 13a-c …
Novel piperazine–chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer …
MF Ahmed, EY Santali, R El-Haggar - Journal of enzyme inhibition …, 2021 - Taylor & Francis
New piperazine–chalcone hybrids and related pyrazoline derivatives have been designed
and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) …
and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) …
The effect of novel synthetic semicarbazone-and thiosemicarbazone-linked 1, 2, 3-triazoles on the apoptotic markers, VEGFR-2, and cell cycle of myeloid leukemia
Abstract Vascular Endothelial Growth Factor II (VEGFR-2) has been proved as a rational
target in cancer therapy. Although currently prescribed VEGFR-2 inhibitors are showing …
target in cancer therapy. Although currently prescribed VEGFR-2 inhibitors are showing …
[HTML][HTML] Targeting tumor cells with pyrazolo [3, 4-d] pyrimidine scaffold: A literature review on synthetic approaches, structure activity relationship, structural and target …
Abstract Pyrazolo [3, 4-d] pyrimidine had been attracted awesome interest due to its
pharmacological potential especially as an anticancer. Several mechanisms of action were …
pharmacological potential especially as an anticancer. Several mechanisms of action were …
Design, synthesis and antitumor activity of novel pyrazolo [3, 4-d] pyrimidine derivatives as EGFR-TK inhibitors
MA Abdelgawad, RB Bakr, OA Alkhoja… - Bioorganic chemistry, 2016 - Elsevier
Abstract A novel series of 2-(3, 6-dimethyl-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4-yloxy)-
N-(4-substitutedbenzylidene) acetohydrazide (12a–g) was prepared and their structures …
N-(4-substitutedbenzylidene) acetohydrazide (12a–g) was prepared and their structures …
Design, synthesis, and docking studies of novel pyrazole-based scaffolds and their evaluation as VEGFR2 inhibitors in the treatment of prostate cancer
DH Soliman, MS Nafie - RSC advances, 2023 - pubs.rsc.org
Since VEGFR-2 plays a crucial role in tumor growth, angiogenesis, and metastasis, it is a
prospective target for cancer treatment. In this work, a series of 3-phenyl-4-(2-substituted …
prospective target for cancer treatment. In this work, a series of 3-phenyl-4-(2-substituted …
New pyrimidine-benzoxazole/benzimidazole hybrids: Synthesis, antioxidant, cytotoxic activity, in vitro cyclooxygenase and phospholipase A2-V inhibition
To enhance the cytotoxicity of benzimidazole and/or benzoxazole core, the benzimidazole/
benzoxazole azo-pyrimidine were synthesized through diazo-coupling of 3 …
benzoxazole azo-pyrimidine were synthesized through diazo-coupling of 3 …