We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …

Identification of modifiable risk factors provides a crucial approach to the prevention of
dementia. Nutritional or nutrient-dependent risk factors are especially important because …

Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly people,
but there are still no curative options. Senile plaques and neurofibrillary tangles are …

The biosynthesis of B 12, involving up to 30 different enzyme-mediated steps, only occurs in
bacteria. Thus, most eukaryotes require an external source of B 12, and yet the vitamin …

Mild cognitive impairment (MCI) is defined as an intermediate state between normal
cognitive aging and dementia. It describes a status of the subjective impression of cognitive …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

There are numerous theories of aging, a process which still seems inevitable. Aging leads to
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …

A simple molecule, tetrafluoroterephthalonitrile (4F-2CN), was discovered to be an efficient
fluorescent probe for detecting biological thiol species. The probe responded to Cys and …