Tumor immune escape is an important strategy of tumor survival. There are many
mechanisms of tumor immune escape, including immunosuppression, which has become a …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily
affects joints. The several mechanisms involved in the development of the disease are not …

Background Peresolimab is a humanized IgG1 monoclonal antibody designed to stimulate
the endogenous programmed cell death protein 1 (PD-1) inhibitory pathway. Stimulation of …

Simple Summary The interaction of programmed cell death ligand-1 (PDL1) with its receptor
PD1 inhibits T-cell responses. Blockade of this interaction with monoclonal antibodies leads …

Immune checkpoint molecules are promising anticancer targets, among which therapeutic
antibodies targeting the PD-1/PD-L1 pathway have been widely applied to cancer treatment …

Successful therapeutic stratification will depend upon an increasingly sophisticated
appreciation of how dominant players amongst cytokine networks vary across time and …

Recent advances in the treatment of various cancers have resulted in the adaptation of
several novel immunotherapeutic strategies. Notably, the recent intervention through …

Background Blocking the programmed death protein 1 (PD-1)/programmed death-ligand 1
(PD-L1) pathway in hepatocellular carcinoma (HCC) is a very promising approach in …

Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated
antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and …

Chronic inflammatory diseases are characterized by recurrent inflammatory attacks in the
tissues mediated by autoreactive T cells. Identity and functional programming of CD8+ T …