What makes Yarrowia lipolytica well suited for industry?

YK Park, R Ledesma-Amaro - Trends in Biotechnology, 2023 - cell.com
Yarrowia lipolytica possesses natural and engineered traits that make it a good host for the
industrial bioproduction of chemicals, fuels, foods, and pharmaceuticals. In recent years …

Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

Recombination machinery engineering facilitates metabolic engineering of the industrial yeast Pichia pastoris

P Cai, X Duan, X Wu, L Gao, M Ye… - Nucleic Acids …, 2021 - academic.oup.com
The industrial yeast Pichia pastoris has been harnessed extensively for production of
proteins, and it is attracting attention as a chassis cell factory for production of chemicals …

Yarrowia lipolytica Strains and Their Biotechnological Applications: How Natural Biodiversity and Metabolic Engineering Could Contribute to Cell Factories …

C Madzak - Journal of Fungi, 2021 - mdpi.com
Among non-conventional yeasts of industrial interest, the dimorphic oleaginous yeast
Yarrowia lipolytica appears as one of the most attractive for a large range of white …

Advances in industrial biotechnology using CRISPR-Cas systems

PD Donohoue, R Barrangou, AP May - Trends in biotechnology, 2018 - cell.com
The term 'clustered regularly interspaced short palindromic repeats'(CRISPR) has recently
become synonymous with the genome-editing revolution. The RNA-guided endonuclease …

Metabolic engineering in the host Yarrowia lipolytica

AM Abdel-Mawgoud, KA Markham, CM Palmer… - Metabolic …, 2018 - Elsevier
The nonconventional, oleaginous yeast, Yarrowia lipolytica is rapidly emerging as a
valuable host for the production of a variety of both lipid and nonlipid chemical products …

Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

A Madhavan, KB Arun, R Sindhu… - Microbial Cell …, 2021 - Springer
The manufacture of recombinant therapeutics is a fastest-developing section of therapeutic
pharmaceuticals and presently plays a significant role in disease management. Yeasts are …

Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity

Z Luo, N Liu, Z Lazar, A Chatzivasileiou, V Ward… - Metabolic …, 2020 - Elsevier
The abundant supply of biosynthetic precursors and product compatibility with the
intracellular environment play important roles for microbial isoprenoid production. In this …

EasyCloneYALI: CRISPR/Cas9‐Based Synthetic Toolbox for Engineering of the Yeast Yarrowia lipolytica

C Holkenbrink, MI Dam, KR Kildegaard… - Biotechnology …, 2018 - Wiley Online Library
The oleaginous yeast Yarrowia lipolytica is an emerging host for production of fatty acid‐
derived chemicals. To enable rapid iterative metabolic engineering of this yeast, there is a …

[HTML][HTML] Synthetic biology tools for engineering Yarrowia lipolytica

M Larroudé, T Rossignol, JM Nicaud… - Biotechnology …, 2018 - Elsevier
The non-conventional oleaginous yeast Yarrowia lipolytica shows great industrial promise. It
naturally produces certain compounds of interest but can also artificially generate non-native …