BACKGROUND The key to a more effective diagnosis, prognosis, and therapeutic
management of prostate cancer (PCa) could lie in the direct analysis of cancer tissue. In this …

Severe COVID-19 disease leads to hypoxemia, inflammation and lymphopenia. Viral
infection induces cellular stress and causes the activation of the innate immune response …

The ductus arteriosus (DA) connects the aorta to the pulmonary artery (PA), directing
placentally oxygenated blood away from the developing lungs. High pulmonary vascular …

Most solid tumours are hypoxic. Tumour cell proliferation and metabolism accelerate oxygen
consumption. The low oxygen supply due to vascular abnormalisation and the high oxygen …

Pulmonary hypertension (PH) is a severe progressive disease, and the uncontrolled
proliferation of pulmonary artery smooth muscle cells (PASMCs) is one of the main causes …

Background Evaluating and controlling confounders are necessary when investigating
molecular pathogenesis using human postmortem brain tissue. Particularly, tissue pH and …

Proteolytic systems exert an important role in vertebrate muscle controlling protein turnover,
recycling of amino acids (AA) or its use for energy production, as well as other functions like …

Background/Aims: The main aim of this study was to determine the mechanisms by which
rno-miR-210-3p affects changes in gene expression, metabolism, apoptosis and …

Background Pulmonary artery hypertension (PAH), which is characterized by an increase in
pulmonary circulation blood pressure, is a fatal disease, and its pathogenesis remains …

Pulmonary hypertension (PH) is a fatal syndrome that arises from a multifactorial and
complex background, is characterized by increased pulmonary vascular resistance and right …