Potassium regulates a plethora of metabolic and developmental response in plants, and
upon exposure to biotic and abiotic stresses a substantial K+ loss occurs from plant cells …

Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological
impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic …

Background Prior studies have revealed remarkable phenotypic heterogeneity in KCNQ2-
related disorders, correlated with effects on biophysical features of heterologously …

Background Isovaleric acid (IVA) is a 5-carbon branched-chain fatty acid present in
fermented foods and produced in the colon by bacterial fermentation of leucine. We …

Lipids influence powerfully the function of ion channels and transporters in two well-
documented ways. A few lipids act as bona fide second messengers by binding to specific …

Transmembrane 16A (TMEM16A, anoctamin1), 1 of 10 TMEM16 family proteins, is a Cl−
channel activated by intracellular Ca2+ and membrane voltage. This channel is also …

Dysfunctional dopamine signaling is implicated in various neuropsychological disorders.
Previously, we reported that dopamine increases D1 receptor (D1R)-expressing medium …

Voltage-sensing phosphatase (VSP) contains a voltage sensor domain (VSD) similar to that
in voltage-gated ion channels, and a phosphoinositide phosphatase region similar to …

M-type (Kv7, KCNQ) potassium channels are proteins that control the excitability of neurons
and muscle cells. Many physiological and pathological mechanisms of excitation operate via …

The evolution of novel motor behaviors requires modifications in the central pattern
generators (CPGs) controlling muscle activity. How such changes gradually lead to novel …