Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Estrogen governs the regulations of various pathological and physiological actions
throughout the body in both males and females. Generally, 17β-estradiol an endogenous …

Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

The mammalian sirtuin family has attracted tremendous attention over the past few years as
stress adaptors and post-translational modifier. They have involved in diverse cellular …

Aging is characterized by progressive functional deterioration with increased risk of
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …

The saturated medium-chain fatty-acid lauric acid (LA) has been associated to certain health-
promoting benefits of coconut oil intake, including the improvement of the quality of life in …

Sex steroids have been widely described to be associated with a number of human
diseases, including hormone-dependent tumors. Several studies have been concerned …

In recent months, the coronavirus disease 2019 (COVID-19) pandemic has sent many
countries into crisis. Studies have shown that this virus causes worse outcomes and a higher …

Copper promotes tumor angiogenesis, nevertheless the mechanisms involved remain to be
fully understood. We have recently demonstrated that the G-protein estrogen receptor …

Cancer is a major public health issue and represents the second leading cause of death in
women worldwide, as female reproductive-related neoplasms are the main cause of …