The global rise in the prevalence of obesity and associated co-morbidities such as type 2
diabetes, cardiovascular disease, and cancer represents a major public health concern. The …

Prader-Willi syndrome (PWS) is a rare neurodevelopmental genetic disorder associated with
a characteristic behavioral phenotype that includes severe hyperphagia and a variety of …

The brain is the seat of body weight homeostasis. However, our inability to control the
increasing prevalence of obesity highlights a need to look beyond canonical feeding …

Objective: The objective of the study was to provide recommendations for the diagnosis and
management of Prader-Willi syndrome throughout the life span to guide clinical practice …

In a small fraction of mammalian genes—at present estimated at less than 1% of the total—
one of the two alleles that is inherited by the offspring is partially or completely switched off …

Prader-Willi syndrome (PWS) is the leading genetic cause of obesity. After initial severe
hypotonia, PWS children become hyperphagic and morbidly obese, if intake is not restricted …

The prosocial neuropeptide oxytocin is being developed as a potential treatment for various
neuropsychiatric disorders including autism spectrum disorder (ASD). Early studies using …

The expression of emotions and internal states by individuals with severe or profound
intellectual disabilities is a comparatively under-researched area. Comprehensive or …

Background: The majority of research on obesity (OB) has focused primarily on clinical
features (eating behavior, adiposity measures) or peripheral appetite-regulatory peptides …

Abstract Prader–Willi Syndrome (PWS) is a genetically determined neurodevelopmental
disorder associated with mild to moderate intellectual disability, growth and sex-hormone …