Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

Physiological signaling functions of reactive oxygen species in stem cells: from flies to man

SA Sinenko, TY Starkova, AA Kuzmin… - Frontiers in cell and …, 2021 - frontiersin.org
Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

Cadmium-induced oxidative stress: focus on the central nervous system

JJV Branca, C Fiorillo, D Carrino, F Paternostro… - Antioxidants, 2020 - mdpi.com
Cadmium (Cd), a category I human carcinogen, is a well-known widespread environmental
pollutant. Chronic Cd exposure affects different organs and tissues, such as the central …

Mitochondrial dynamics, ROS, and cell signaling: a blended overview

V Brillo, L Chieregato, L Leanza, S Muccioli, R Costa - Life, 2021 - mdpi.com
Mitochondria are key intracellular organelles involved not only in the metabolic state of the
cell, but also in several cellular functions, such as proliferation, Calcium signaling, and lipid …

[HTML][HTML] Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights

SA Mason, AJ Trewin, L Parker, GD Wadley - Redox biology, 2020 - Elsevier
Antioxidant supplements are commonly consumed by endurance athletes to minimize
exercise-induced oxidative stress, with the intention of enhancing recovery and improving …

Spatial and temporal control of mitochondrial H2O2 release in intact human cells

MN Hoehne, LJHC Jacobs, KJ Lapacz… - The EMBO …, 2022 - embopress.org
Abstract Hydrogen peroxide (H2O2) has key signaling roles at physiological levels, while
causing molecular damage at elevated concentrations. H2O2 production by mitochondria is …

[HTML][HTML] Immune cell-produced ROS and their impact on tumor growth and metastasis

KB Kennel, FR Greten - Redox Biology, 2021 - Elsevier
Reactive oxygen species (ROS) are derivatives of molecular oxygen (O 2) involved in
various physiological and pathological processes. In immune cells, ROS are mediators of …

Modelling mitochondrial ROS production by the respiratory chain

JP Mazat, A Devin, S Ransac - Cellular and Molecular Life Sciences, 2020 - Springer
ROS (superoxide and oxygen peroxide in this paper) play a dual role as signalling
molecules and strong oxidizing agents leading to oxidative stress. Their production mainly …

Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed In Vivo and In Vitro

MLM Hardy, ML Day, MB Morris - International Journal of Environmental …, 2021 - mdpi.com
Oocytes and preimplantation embryos require careful regulation of the redox environment
for optimal development both in vivo and in vitro. Reactive oxygen species (ROS) are …

[HTML][HTML] Mitochondria as intracellular signalling organelles. An update

LD Popov - Cellular Signalling, 2023 - Elsevier
Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …