Spinal cord hemisection at C2 (C2SH), sparing the dorsal column is widely used to
investigate the effects of reduced phrenic motor neuron (PhMN) activation on diaphragm …

Proinflammatory cytokines such as TNFα mediate airway inflammation. Previously, we
showed that TNFα increases mitochondrial biogenesis in human ASM (hASM) cells, which is …

An increase in astrocyte reactivity has been described in Alzheimer's disease and seems to
be related to the presence of a pro-inflammatory environment. Reactive astrocytes show an …

Cellular mitochondrial function can be assessed using high-resolution respirometry that
measures the O2 consumption rate (OCR) across a number of cells. However, a direct …

Succinate dehydrogenase (SDH) is a key mitochondrial enzyme involved in the tricarboxylic
acid cycle, where it facilitates the oxidation of succinate to fumarate, and is coupled to the …

Neuromotor control of diaphragm muscle (DIAm) motor units is dependent on an orderly size-
dependent recruitment of phrenic motor neurons (PhMNs). Slow (type S) and fast, fatigue …

Cervical spinal cord injury impacts ventilatory and non‐ventilatory functions of the
diaphragm muscle (DIAm) and contributes to clinical morbidity and mortality in the afflicted …

Following cSCI, activation of the DIAm can be impacted depending on the extent of the
injury. The present manuscript describes a unilateral C2 hemisection (C2SH) model of cSCI …

The internal globus pallidus (GPi) is a major source of tonic GABAergic inhibition to the
motor thalamus. In parkinsonism, the firing rate of GPi neurons is increased, and their …