[HTML][HTML] Long non-coding RNA in the pathogenesis of cancers

Y Chi, D Wang, J Wang, W Yu, J Yang - Cells, 2019 - mdpi.com
The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

[PDF][PDF] The role of non-coding RNAs in oncology

FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

[PDF][PDF] lncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway.

GH Wei, X Wang - European Review for Medical & …, 2017 - europeanreview.org
OBJECTIVE: lncRNA MEG3 has been reported as a tumor suppressor gene in many
different kinds of cancer, but its role in gastric cancer has not been fully understood. Then …

[HTML][HTML] Apoptosis, autophagy, necroptosis, and cancer metastasis

Z Su, Z Yang, Y Xu, Y Chen, Q Yu - Molecular cancer, 2015 - Springer
Metastasis is a crucial hallmark of cancer progression, which involves numerous factors
including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal …

[HTML][HTML] Functions of lncRNA HOTAIR in lung cancer

G Loewen, J Jayawickramarajah, Y Zhuo… - Journal of hematology & …, 2014 - Springer
Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes.
lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through …

[HTML][HTML] CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived …

P Wang, R Mokhtari, E Pedrosa, M Kirschenbaum… - Molecular autism, 2017 - Springer
Background CHD8 (chromodomain helicase DNA-binding protein 8), which codes for a
member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the …

[PDF][PDF] Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway

T Uroda, E Anastasakou, A Rossi, JM Teulon… - Molecular cell, 2019 - cell.com
Long non-coding RNAs (lncRNAs) are key regulatory molecules, but unlike with other RNAs,
the direct link between their tertiary structure motifs and their function has proven elusive …

Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21

J Zhang, T Yao, Y Wang, J Yu, Y Liu… - Cancer biology & …, 2016 - Taylor & Francis
Recent research has found that long noncoding RNAs (lncRNAs) were involved in various
human cancers. However, the role of these lncRNAs in cervical cancer remains unexplored …

[HTML][HTML] Regulation of lncRNA and its role in cancer metastasis

J Li, H Meng, Y Bai, K Wang - Oncology research, 2016 - ncbi.nlm.nih.gov
Metastasis is the primary cause of cancer-related death all over the world. Metastasis is a
process by which cancer spreads from the place at which it first arose to distant locations in …

[HTML][HTML] Maternally expressed gene 3 (MEG3): A tumor suppressor long non coding RNA

S Ghafouri-Fard, M Taheri - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Abstract Maternally expressed gene 3 (MEG3) is a long non-coding RNA (lncRNA) located
on chromosome 14q32. 3. Direct sequencing experiments have shown monoallelic …