Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS

P Willner - Neuropsychobiology, 2005 - karger.com
The chronic mild stress (CMS) model of depression has high validity but has in the past
been criticized for being difficult to replicate. However, a large number of recent publications …

Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets

C Ramassamy - European journal of pharmacology, 2006 - Elsevier
Aging is the major risk factor for neurodegenerative diseases such as Alzheimer's and
Parkinson's diseases. A large body of evidence indicates that oxidative stress is involved in …

A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects

KA Youdim, JA Joseph - Free Radical Biology and Medicine, 2001 - Elsevier
It is rare to see a day pass in which we are not told through some popular medium that the
population is becoming older. Along with this information comes the “new” revelation that as …

Studies on molecular mechanisms of Ginkgo biloba extract

JV Smith, Y Luo - Applied microbiology and biotechnology, 2004 - Springer
In the past decade, interest by the general public in the use of herbal dietary supplements
has risen exponentially. As throughout history, individuals are now turning to the use of …

Dietary flavonoids as potential neuroprotectants

KA Youdim, JPE Spencer, H Schroeter, C Rice-Evans - 2002 - degruyter.com
There is an increasing awareness of the role of certain nutritional components, including
dietary flavonoids found in fruit, vegetables and beverages, in the maintenance of health …

Monoamine oxidase expression during development and aging

A Nicotra, F Pierucci, H Parvez, O Senatori - Neurotoxicology, 2004 - Elsevier
Monoamine oxidase (MAO) isoenzymes play a major role in regulating the concentration of
several bioactive amines, including serotonin and catecholamines. Both in the nervous …

The Ginkgo biloba extract EGb 761® and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex

T Yoshitake, S Yoshitake, J Kehr - British Journal of …, 2010 - Wiley Online Library
Background and purpose: Experimental and clinical data suggest that extracts of Ginkgo
biloba improve cognitive function. However, the neurochemical correlates of these effects …

Monoamine oxidase inhibitors as neuroprotective agents in age-dependent neurodegenerative disorders

M Naoi, W Maruyama - Current pharmaceutical design, 2010 - ingentaconnect.com
Alzheimer's and Parkinson's diseases are the most common neurodegenerative disorders
among the aged. The etiologies of these diseases remain to be clarified, but the common …

Ginkgo biloba leaf extract (EGb 761®) and its specific acylated flavonol constituents increase dopamine and acetylcholine levels in the rat medial prefrontal cortex …

J Kehr, S Yoshitake, S Ijiri, E Koch… - International …, 2012 - cambridge.org
Experimental and clinical data suggest that the Ginkgo biloba standardized extract EGb
761® exerts beneficial effects in conditions which are associated with impaired cognitive …

Life span extension and cancer risk: myths and reality

VN Anisimov - Experimental gerontology, 2001 - Elsevier
A significant increase in the number of old people in the populations of developed countries
was followed by an increase in morbidity and mortality resulting from main age-related …