α-Synuclein in synaptic function and dysfunction

M Sharma, J Burré - Trends in neurosciences, 2023 - cell.com
Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease

EM Rocha, B De Miranda, LH Sanders - Neurobiology of disease, 2018 - Elsevier
Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …

The vermiform appendix impacts the risk of developing Parkinson's disease

BA Killinger, Z Madaj, JW Sikora, N Rey… - Science translational …, 2018 - science.org
The pathogenesis of Parkinson's disease (PD) involves the accumulation of aggregated α-
synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we …

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

N Ramalingam, SX Jin, TE Moors… - npj Parkinson's …, 2023 - nature.com
In Parkinson's disease and other synucleinopathies, the elevation of α-synuclein
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …

Implication of alpha-synuclein phosphorylation at S129 in synucleinopathies: what have we learned in the last decade?

A Oueslati - Journal of Parkinson's disease, 2016 - content.iospress.com
Abnormal accumulation of proteinaceous intraneuronal inclusions called Lewy bodies (LBs)
is the neurpathological hallmark of Parkinson's disease (PD) and related synucleinopathies …

Alpha-synuclein biology in Lewy body diseases

WS Kim, K Kågedal, GM Halliday - Alzheimer's research & therapy, 2014 - Springer
Abstract α-Synuclein is an abundantly expressed neuronal protein that is at the center of
focus in understanding a group of neurodegenerative disorders called α-synucleinopathies …

Best practices for generating and using alpha-synuclein pre-formed fibrils to model Parkinson's disease in rodents

NK Polinski, LA Volpicelli-Daley… - Journal of …, 2018 - content.iospress.com
Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting
approximately onepercent of the population over the age of sixty. Although many animal …

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease

KE Murphy, AM Gysbers, SK Abbott, N Tayebi, WS Kim… - Brain, 2014 - academic.oup.com
Heterozygous mutations in GBA1, the gene encoding lysosomal glucocerebrosidase, are
the most frequent known genetic risk factor for Parkinson's disease. Reduced …

Pathogenic impact of α-synuclein phosphorylation and its kinases in α-synucleinopathies

I Kawahata, DI Finkelstein, K Fukunaga - International journal of …, 2022 - mdpi.com
α-Synuclein is a protein with a molecular weight of 14.5 kDa and consists of 140 amino
acids encoded by the SNCA gene. Missense mutations and gene duplications in the SNCA …

Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts

KA Jellinger - Movement disorders, 2012 - Wiley Online Library
Abstract Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is
no longer considered a complex motor disorder characterized by extrapyramidal symptoms …