The fibroblast growth factor signaling pathway
DM Ornitz, N Itoh - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23
C Bergwitz, H Jüppner - Annual review of medicine, 2010 - annualreviews.org
In contrast to the regulation of calcium homeostasis, which has been extensively studied
over the past several decades, relatively little is known about the regulation of phosphate …
over the past several decades, relatively little is known about the regulation of phosphate …
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
R Goetz, Y Nakada, MC Hu, H Kurosu… - Proceedings of the …, 2010 - National Acad Sciences
Fibroblast growth factor (FGF) 23 inhibits renal phosphate reabsorption by activating FGF
receptor (FGFR) 1c in a Klotho-dependent fashion. The phosphaturic activity of FGF23 is …
receptor (FGFR) 1c in a Klotho-dependent fashion. The phosphaturic activity of FGF23 is …
Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes
R Hecht, YS Li, J Sun, E Belouski, M Hall, T Hager… - PloS one, 2012 - journals.plos.org
Fibroblast growth factor 21 (FGF21) is a promising drug candidate for the treatment of type 2
diabetes. However, the use of wild type native FGF21 is challenging due to several …
diabetes. However, the use of wild type native FGF21 is challenging due to several …
Hypophosphatemia: the common denominator of all rickets
D Tiosano, Z Hochberg - Journal of bone and mineral metabolism, 2009 - Springer
Rickets is a disease of the hypertrophic chondrocytes in the growth plate and is caused by
hypophosphatemia—a derived defect in terminal chondrocyte apoptosis. This highlights the …
hypophosphatemia—a derived defect in terminal chondrocyte apoptosis. This highlights the …
Regulation of fibroblast growth factor 23 (FGF 23) in health and disease
L Bär, C Stournaras, F Lang, M Föller - FEBS letters, 2019 - Wiley Online Library
Fibroblast growth factor 23 (FGF 23) is mainly produced in the bone and, upon secretion,
forms a complex with a FGF receptor and coreceptor αKlotho. FGF 23 can exert several …
forms a complex with a FGF receptor and coreceptor αKlotho. FGF 23 can exert several …
Endocrine FGFs: evolution, physiology, pathophysiology, and pharmacotherapy
N Itoh, H Ohta, M Konishi - Frontiers in endocrinology, 2015 - frontiersin.org
The human fibroblast growth factor (FGF) family comprises 22 structurally related
polypeptides that play crucial roles in neuronal functions, development, and metabolism …
polypeptides that play crucial roles in neuronal functions, development, and metabolism …
Multilineage somatic activating mutations in HRAS and NRAS cause mosaic cutaneous and skeletal lesions, elevated FGF23 and hypophosphatemia
YH Lim, D Ovejero, JS Sugarman… - Human molecular …, 2014 - academic.oup.com
Pathologically elevated serum levels of fibroblast growth factor-23 (FGF23), a bone-derived
hormone that regulates phosphorus homeostasis, result in renal phosphate wasting and …
hormone that regulates phosphorus homeostasis, result in renal phosphate wasting and …
Clinical variability of familial tumoral calcinosis caused by novel GALNT3 mutations
S Ichikawa, G Baujat, A Seyahi… - American journal of …, 2010 - Wiley Online Library
The GALNT3 gene encodes GalNAc‐T3, which prevents degradation of the phosphaturic
hormone, fibroblast growth factor 23 (FGF23). Biallelic mutations in either GALNT3 or FGF23 …
hormone, fibroblast growth factor 23 (FGF23). Biallelic mutations in either GALNT3 or FGF23 …
Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia
The transgenic and knockout (KO) animals involving Fgf23 have been highly informative in
defining novel aspects of mineral metabolism, but are limited by shortened lifespan, inability …
defining novel aspects of mineral metabolism, but are limited by shortened lifespan, inability …