Effect of glycosylation on antibody function: implications for genetic engineering

A Wright, SL Morrison - Trends in biotechnology, 1997 - cell.com
Antibodies are able to both bind antigens and trigger the responses that eliminate them from
circulation. All antibodies are glycosylated at conserved positions in their constant regions …

Getting the glycosylation right: implications for the biotechnology industry

N Jenkins, RB Parekh, DC James - Nature biotechnology, 1996 - nature.com
Glycosylation is the most extensive of all the posttranslational modifications, and has
important functions in the secretion, antigenicity and clearance of glycoproteins. In recent …

Letter to the Glyco-Forum: Effective glycoanalysis with Maackia amurensis lectins requires a clear understanding of their binding specificities

C Geisler, DL Jarvis - Glycobiology, 2011 - academic.oup.com
Many researchers use MAL (Maackia amurensis leukoagglutinin) and MAH (M. amurensis
hemagglutinin), the seed lectins from M. amurensis, as glycoanalytical tools to probe …

[HTML][HTML] Low‐affinity nerve‐growth factor receptor (P75NTR) can serve as a receptor for rabies virus

C Tuffereau, J Bénéjean, D Blondel, B Kieffer… - The EMBO …, 1998 - embopress.org
A random‐primed cDNA expression library constructed from the mRNA of neuroblastoma
cells (NG108) was used to clone a specific rabies virus (RV) receptor. A soluble form of the …

Heterologous expression of membrane proteins: choosing the appropriate host

F Bernaudat, A Frelet-Barrand, N Pochon, S Dementin… - PloS one, 2011 - journals.plos.org
Background Membrane proteins are the targets of 50% of drugs, although they only
represent 1% of total cellular proteins. The first major bottleneck on the route to their …

Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice

T Abe, H Takahashi, H Hamazaki… - The Journal of …, 2003 - journals.aai.org
A recombinant baculovirus expressing the hemagglutinin gene of the influenza virus,
A/PR/8/34 (H1N1), under the control of the chicken β-actin promoter, was constructed. To …

[图书][B] The baculoviruses

L Miller - 1997 - books.google.com
The past decade has witnessed an explosion of information on the molecular biology of
insect viruses and a frenzy of activity in applying this information to medicine and agriculture …

Involvement of the Toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus

T Abe, H Hemmi, H Miyamoto, K Moriishi… - Journal of …, 2005 - Am Soc Microbiol
We have previously shown that mice inoculated intranasally with a wild-type baculovirus
(Autographa californica nuclear polyhedrosis virus [AcNPV]) are protected from a lethal …

[HTML][HTML] Developing baculovirus-insect cell expression systems for humanized recombinant glycoprotein production

DL Jarvis - Virology, 2003 - Elsevier
The baculovirus-insect cell expression system is widely used to produce recombinant
glycoproteins for many different biomedical applications. However, due to the fundamental …

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

S Hervas-Stubbs, P Rueda, L Lopez… - The Journal of …, 2007 - journals.aai.org
Baculoviruses (BVs) are dsDNA viruses that are pathogenic for insects. They have been
used worldwide as selective bioinsecticides and for producing recombinant proteins in …