α7-and α9-containing nicotinic acetylcholine receptors in the functioning of immune system and in pain

I Shelukhina, A Siniavin, I Kasheverov… - International Journal of …, 2023 - mdpi.com
Nicotinic acetylcholine receptors (nAChRs) present as many different subtypes in the
nervous and immune systems, muscles and on the cells of other organs. In the immune …

α9-containing nicotinic receptors in cancer

S Pucci, M Zoli, F Clementi, C Gotti - Frontiers in Cellular …, 2022 - frontiersin.org
Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are
expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly …

α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer

Q Zhang, Y Jia, P Pan, X Zhang, Y Jia, P Zhu… - …, 2022 - academic.oup.com
The α5-nicotinic acetylcholine receptor (α5-nAChR) is closely associated with nicotine-
related lung cancer, offering a novel perspective for investigating the molecular …

[HTML][HTML] Genomic, transcriptomic, and epigenomic analysis of a medicinal snake, Bungarus multicinctus, to provides insights into the origin of Elapidae neurotoxins

J Xu, S Guo, X Yin, M Li, H Su, X Liao, Q Li, L Le… - … Pharmaceutica Sinica B, 2023 - Elsevier
The many-banded krait, Bungarus multicinctus, has been recorded as the animal resource
of JinQianBaiHuaShe in the Chinese Pharmacopoeia. Characterization of its venoms …

Three‐finger proteins from snakes and humans acting on nicotinic receptors: Old and new

VI Tsetlin, IE Kasheverov, YN Utkin - Journal of Neurochemistry, 2021 - Wiley Online Library
The first toxin to give rise to the three‐finger protein (TFP) family was α‐bungarotoxin (α‐Bgt)
from Bungarus multicinctus krait venom. α‐Bgt was crucial for research on nicotinic …

Inhibition of nicotinic acetylcholine receptors by oligoarginine peptides and polyamine-related compounds

LO Ojomoko, EV Kryukova, NS Egorova… - Frontiers in …, 2023 - frontiersin.org
Oligoarginine peptides, known mostly for their cell-penetrating properties, are also inhibitors
of the nicotinic acetylcholine receptors (nAChRs). Since octa-arginine (R8) inhibits α9α10 …

Lynx1 prototoxins: critical accessory proteins of neuronal nicotinic acetylcholine receptors

JM Miwa - Current opinion in pharmacology, 2021 - Elsevier
Nicotinic receptors of the cholinergic system are ligand-gated ion channels, responding to
the excitatory neurotransmitter, acetylcholine, and the addictive component of tobacco …

[HTML][HTML] Biomedical applications of synthetic peptides derived from venom of animal origin: A systematic review

JL Diaz-Gomez, I Martin-Estal, E Rivera-Aboytes… - Biomedicine & …, 2024 - Elsevier
Abstract Development of therapeutic agents that have fewer adverse effects and have higher
efficacy for diseases, such as cancer, metabolic disorders, neurological diseases, infections …

[HTML][HTML] Biochemical basis of skin disease Mal de Meleda: SLURP-1 mutants differently affect keratinocyte proliferation and apoptosis

MA Shulepko, ML Bychkov, ZO Shenkarev… - Journal of Investigative …, 2021 - Elsevier
Mal de Meleda is an autosomal recessive palmoplantar keratoderma associated with
mutations in a gene encoding SLURP-1. SLURP-1 controls growth, differentiation, and …

Non-conventional toxin WTX and its disulfide-fixed synthetic fragments: Interaction with nicotinic acetylcholine receptors and reduction of blood pressure

MS Severyukhina, LO Ojomoko, IV Shelukhina… - International Journal of …, 2024 - Elsevier
Non-conventional snake venom toxins, such as WTX from the cobra Naja kaouthia, are three-
finger proteins containing a fifth disulfide bond in the N-terminal polypeptide loop I and …