Deleterious mutations decrease reproductive fitness and are ubiquitous in genomes. Given
that many organisms face ongoing threats of extinction, there is interest in elucidating the …

Population genetics is transitioning into a data-driven discipline thanks to the availability of
large-scale genomic data and the need to study increasingly complex evolutionary …

Stochastic simulation is a key tool in population genetics, since the models involved are
often analytically intractable and simulation is usually the only way of obtaining ground-truth …

Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …

The vast majority of genome-wide association studies (GWASs) are performed in
Europeans, and their transferability to other populations is dependent on many factors (eg …

The sequencing of modern and ancient genomes from around the world has revolutionized
our understanding of human history and evolution. However, the problem of how best to …

Generative models have shown breakthroughs in a wide spectrum of domains due to recent
advancements in machine learning algorithms and increased computational power. Despite …

Studies in a variety of species have shown evidence for positively selected variants
introduced into a population via introgression from another, distantly related population—a …

Characterizing the population history of a species and identifying loci underlying local
adaptation is crucial in functional ecology, evolutionary biology, conservation and …

Despite the growing number of genome-wide association studies (GWASs), it remains
unclear to what extent gene-by-gene and gene-by-environment interactions influence …