Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis

Q Ye, B Zou, YH Yeo, J Li, DQ Huang, Y Wu… - The lancet …, 2020 - thelancet.com
Background Although non-alcoholic fatty liver disease (NAFLD) is commonly associated
with obesity, it is increasingly being identified in non-obese individuals. We aimed to …

[HTML][HTML] Epidemiology of non-alcoholic and alcoholic fatty liver diseases

S Mitra, A De, A Chowdhury - Translational gastroenterology and …, 2020 - ncbi.nlm.nih.gov
Liver diseases are fast emerging as global health priorities. Fatty liver is described in the
setting of non-alcoholic fatty liver disease (NAFLD) as well as alcoholic liver disease (ALD) …

The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease

M Eslam, SK Sarin, VWS Wong, JG Fan… - Hepatology …, 2020 - Springer
Metabolic associated fatty liver disease (MAFLD) is the principal worldwide cause of liver
disease and affects nearly a quarter of the global population. The objective of this work was …

Liver diseases in the Asia-Pacific region: a lancet gastroenterology & hepatology commission

SK Sarin, M Kumar, M Eslam, J George… - The lancet …, 2020 - thelancet.com
Summary The Asia-Pacific region is home to more than half of the global population and
accounted for 62· 6% of global deaths due to liver diseases in 2015. 54· 3% of global deaths …

Non-alcoholic fatty liver disease–a global public health perspective

ZM Younossi - Journal of hepatology, 2019 - Elsevier
As the epidemics of obesity and type 2 diabetes mellitus increase worldwide, the prevalence
of non-alcoholic fatty liver disease (NAFLD) is increasing proportionately. The subtype of …

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Z Younossi, QM Anstee, M Marietti, T Hardy… - Nature reviews …, 2018 - nature.com
NAFLD is one of the most important causes of liver disease worldwide and will probably
emerge as the leading cause of end-stage liver disease in the coming decades, with the …

New trends on obesity and NAFLD in Asia

JG Fan, SU Kim, VWS Wong - Journal of hepatology, 2017 - Elsevier
Traditionally, obesity and its related diseases have been considered a problem in Western
countries. However, in the past two decades, urbanisation in many Asian countries has led …

Lean NAFLD: a distinct entity shaped by differential metabolic adaptation

F Chen, S Esmaili, GB Rogers, E Bugianesi, S Petta… - Hepatology, 2020 - journals.lww.com
Conclusions This study demonstrates that E. multilocularis can induce T‐cell exhaustion
through inhibitory receptor TIGIT, and that blocking this checkpoint may reverse the …

Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?

R Younes, O Govaere, S Petta, L Miele, D Tiniakos… - Gut, 2022 - gut.bmj.com
Objective The full phenotypic expression of non-alcoholic fatty liver disease (NAFLD) in lean
subjects is incompletely characterised. We aimed to investigate prevalence, characteristics …

Nonalcoholic fatty liver disease

EM Brunt, VWS Wong, V Nobili, CP Day… - Nature reviews Disease …, 2015 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is a disorder characterized by excess accumulation
of fat in hepatocytes (nonalcoholic fatty liver (NAFL)); in up to 40% of individuals, there are …