Adaptations to a hypoxic lifestyle in naked mole-rats

ME Pamenter - Journal of Experimental Biology, 2022 - journals.biologists.com
Hypoxia is one of the strongest environmental drivers of cellular and physiological
adaptation. Although most mammals are largely intolerant of hypoxia, some specialized …

The naked mole-rat as a model for healthy aging

K Oka, M Yamakawa, Y Kawamura… - Annual Review of …, 2023 - annualreviews.org
Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a
maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and …

Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1

H Cheng, R Sebaa, N Malholtra, B Lacoste… - Nature …, 2021 - nature.com
Naked mole-rats are among the most hypoxia-tolerant mammals. During hypoxia, their body
temperature (T b) decreases via unknown mechanisms to conserve energy. In small …

Surprisingly long survival of premature conclusions about naked mole‐rat biology

S Braude, S Holtze, S Begall, J Brenmoehl… - Biological …, 2021 - Wiley Online Library
Naked mole‐rats express many unusual traits for such a small rodent. Their morphology,
social behaviour, physiology, and ageing have been well studied over the past half‐century …

The idiosyncratic physiological traits of the naked mole-rat; a resilient animal model of aging, longevity, and healthspan

R Buffenstein, W Craft - The extraordinary biology of the naked mole-rat, 2021 - Springer
The subterranean-dwelling naked mole-rat (Heterocephalus glaber) is an extremophilic
rodent, able to thrive in the harsh underground conditions of sub-Saharan Northeast Africa …

Mammalian maxilloturbinal evolution does not reflect thermal biology

Q Martinez, J Okrouhlík, R Šumbera, M Wright… - Nature …, 2023 - nature.com
The evolution of endothermy in vertebrates is a major research topic in recent decades that
has been tackled by a myriad of research disciplines including paleontology, anatomy …

The hypoxia tolerance of eight related African mole‐rat species rivals that of naked mole‐rats, despite divergent ventilatory and metabolic strategies in severe hypoxia

CM Ivy, RJ Sprenger, NC Bennett… - Acta …, 2020 - Wiley Online Library
Aims Burrowing mammals tend to be more hypoxia tolerant than non‐burrowing mammals
and rely less on increases in ventilation and more on decreases in metabolic rate to tolerate …

Seasonal Changes in Locomotor Activity Patterns of Wild Social Natal Mole-Rats (Cryptomys hottentotus natalensis)

KT Finn, AK Janse van Vuuren, DW Hart… - Frontiers in Ecology …, 2022 - frontiersin.org
Differences in individual locomotor activity patterns may be linked to a number of ecological
factors, such as changes in ambient temperature or photoperiod. Observations on …

Energetics and water flux in the subterranean rodent family Bathyergidae

DW Hart, NC Bennett, MK Oosthuizen… - Frontiers in Ecology …, 2022 - frontiersin.org
The doubly labeled water (DLW) technique and indirect calorimetry enable measurement of
an animal's daily energy expenditure (DEE, kJ/day), resting metabolic rate (RMR, kJ/d) …

The evolution and ecology of oxidative and antioxidant status: a comparative approach in African mole-rats

PJ Jacobs, DW Hart, HN Merchant, C Voigt… - Antioxidants, 2023 - mdpi.com
The naked mole-rat of the family Bathyergidae has been the showpiece for ageing research
as they contradict the traditional understanding of the oxidative stress theory of ageing …