[HTML][HTML] Mucosal immunity in COVID-19: a neglected but critical aspect of SARS-CoV-2 infection
MW Russell, Z Moldoveanu, PL Ogra… - Frontiers in …, 2020 - frontiersin.org
The mucosal immune system is the largest component of the entire immune system, having
evolved to provide protection at the main sites of infectious threat: the mucosae. As SARS …
evolved to provide protection at the main sites of infectious threat: the mucosae. As SARS …
[HTML][HTML] Mucosal vaccines for SARS-CoV-2: triumph of hope over experience
D Pilapitiya, AK Wheatley, HX Tan - EBioMedicine, 2023 - thelancet.com
Currently approved COVID-19 vaccines administered parenterally induce robust systemic
humoral and cellular responses. While highly effective against severe disease, there is …
humoral and cellular responses. While highly effective against severe disease, there is …
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages
Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …
around the time of activation of the adaptive immune response. Here, we provide evidence …
[HTML][HTML] N-glycosylation and inflammation; the not-so-sweet relation
B Radovani, I Gudelj - Frontiers in immunology, 2022 - frontiersin.org
Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …
[HTML][HTML] Antibody effector functions are associated with protection from respiratory syncytial virus
Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory tract
infection and death in young infants and the elderly. With no effective prophylactic treatment …
infection and death in young infants and the elderly. With no effective prophylactic treatment …
[HTML][HTML] Sialylation as an important regulator of antibody function
Antibodies play a critical role in linking the adaptive immune response to the innate immune
system. In humans, antibodies are categorized into five classes, IgG, IgM, IgA, IgE, and IgD …
system. In humans, antibodies are categorized into five classes, IgG, IgM, IgA, IgE, and IgD …
[HTML][HTML] Advances in IgA glycosylation and its correlation with diseases
L Ding, X Chen, H Cheng, T Zhang, Z Li - Frontiers in chemistry, 2022 - frontiersin.org
Immunoglobulin A (IgA) is the most abundant immunoglobulin synthesized in the human
body. It has the highest concentration in the mucosa and is second only to IgG in serum. IgA …
body. It has the highest concentration in the mucosa and is second only to IgG in serum. IgA …
[HTML][HTML] Role of the humoral immune response during COVID-19: guilty or not guilty?
M Yaugel-Novoa, T Bourlet, S Paul - Mucosal Immunology, 2022 - Elsevier
Systemic and mucosal humoral immune responses are crucial to fight respiratory viral
infections in the current pandemic of COVID-19 caused by the SARS-CoV-2 virus. During …
infections in the current pandemic of COVID-19 caused by the SARS-CoV-2 virus. During …
[HTML][HTML] Role of polymeric immunoglobulin receptor in IgA and IgM transcytosis
H Wei, JY Wang - International Journal of Molecular Sciences, 2021 - mdpi.com
Transcytosis of polymeric IgA and IgM from the basolateral surface to the apical side of the
epithelium and subsequent secretion into mucosal fluids are mediated by the polymeric …
epithelium and subsequent secretion into mucosal fluids are mediated by the polymeric …
Production and function of immunoglobulin A
TW Hand, A Reboldi - Annual review of immunology, 2021 - annualreviews.org
Among antibodies, IgA is unique because it has evolved to be secreted onto mucosal
surfaces. The structure of IgA and the associated secretory component allow IgA to survive …
surfaces. The structure of IgA and the associated secretory component allow IgA to survive …