Synaptic AMPA receptor composition in development, plasticity and disease

JM Henley, KA Wilkinson - Nature Reviews Neuroscience, 2016 - nature.com
AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate
most fast excitatory neurotransmission. The component subunits determine the functional …

Synaptic memory and CaMKII

RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

AMPARs and synaptic plasticity: the last 25 years

RL Huganir, RA Nicoll - Neuron, 2013 - cell.com
The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …

Long-term potentiation: from CaMKII to AMPA receptor trafficking

BE Herring, RA Nicoll - Annual review of physiology, 2016 - annualreviews.org
For more than 20 years, we have known that Ca2+/calmodulin-dependent protein kinase
(CaMKII) activation is both necessary and sufficient for the induction of long-term …

The corticohippocampal circuit, synaptic plasticity, and memory

J Basu, SA Siegelbaum - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Synaptic plasticity serves as a cellular substrate for information storage in the central
nervous system. The entorhinal cortex (EC) and hippocampus are interconnected brain …

Regulation of NMDA glutamate receptor functions by the GluN2 subunits

M Vieira, XLH Yong, KW Roche… - Journal of …, 2020 - Wiley Online Library
The N‐methyl‐D‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …

How the epigenome integrates information and reshapes the synapse

RR Campbell, MA Wood - Nature Reviews Neuroscience, 2019 - nature.com
In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

Structural insights into binding of therapeutic channel blockers in NMDA receptors

TH Chou, M Epstein, K Michalski, E Fine… - Nature structural & …, 2022 - nature.com
Excitatory signaling mediated by N-methyl-d-aspartate receptor (NMDAR) is critical for brain
development and function, as well as for neurological diseases and disorders. Channel …

The neuroscience of memory: implications for the courtroom

JW Lacy, CEL Stark - Nature Reviews Neuroscience, 2013 - nature.com
Although memory can be hazy at times, it is often assumed that memories of violent or
otherwise stressful events are so well encoded that they are effectively indelible and that …

Rapid active zone remodeling consolidates presynaptic potentiation

MA Böhme, AW McCarthy, AT Grasskamp… - Nature …, 2019 - nature.com
Neuronal communication across synapses relies on neurotransmitter release from
presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic …