Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor
vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical …

One of the most important issues facing cartilage tissue engineering is the inability to move
technologies into the clinic. Despite the multitude of current research in the field, it is known …

The joints of mammals are lined with cartilage, comprised of individual chondrocytes
embedded in a specialized extracellular matrix. Chondrocytes experience a complex …

Extrusion-based bioprinting (EBB) is a rapidly developing technique that has made
substantial progress in the fabrication of constructs for cartilage tissue engineering (CTE) …

Articular cartilage damage is a universal health problem. Despite recent progress,
chondrocyte dedifferentiation has severely compromised the clinical outcomes of cell-based …

Introduction This study aimed to evaluate whether profiles of several soluble mediators in
synovial fluid and cartilage tissue are pathology-dependent and how their production is …

Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment,
as the underlying molecular basis is unclear. Here, we show that DOT1L, an enzyme …

Bioprinting is a promising tool to fabricate organized cartilage. This study aimed to
investigate the printability of gelatin-methacryloyl/gellan gum (gelMA/gellan) hydrogels with …

Articular cartilage exhibits an inherently low rate of regeneration. Consequently, damage to
articular cartilage often requires surgical intervention. However, existing treatments …