Down syndrome (DS) has been recognized as a clinical entity for about 150 years, but it is
only recently that there has been hope for the possibility to understand its pathogenesis and …

Background: The discovery of circulating cell-free fetal nucleic acids in maternal plasma has
opened up new possibilities for noninvasive prenatal diagnosis. The potential application of …

Pyrosequencing is a sequencing-by-synthesis method that quantitatively monitors the real-
time incorporation of nucleotides through the enzymatic conversion of released …

Trisomy 21 is the most common reason that women opt for prenatal diagnosis. Conventional
prenatal diagnostic methods involve the sampling of fetal materials by invasive procedures …

A population of more than six million people worldwide at high risk of Alzheimer's disease
(AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom …

Recent work has demonstrated an unexpected prevalence of copy number variation in the
human genome, and has highlighted the part this variation may play in predisposition to …

Disclosed herein is a system and method for increasing the fidelity of measured genetic
data, for making allele calls, and for determining the state of aneuploidy, in one or a small …

The present disclosure provides methods for determining the ploidy status of a chromosome
in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
67068241&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

First worldwide family litigation filed litigation https://patents. darts-ip. com/? family=
67068241&utm_source= google_patent&utm_medium= platform_link&utm_campaign …