Understanding the Molecular Actions of Spike Glycoprotein in SARS-CoV-2 and Issues of a Novel Therapeutic Strategy for the COVID-19 Vaccine

Y Matsuzaka, R Yashiro - BioMedInformatics, 2024 - mdpi.com
In vaccine development, many use the spike protein (S protein), which has multiple “spike-
like” structures protruding from the spherical structure of the coronavirus, as an antigen …

A mimetic peptide of ACE2 protects against SARS-CoV-2 infection and decreases pulmonary inflammation related to COVID-19

EH Oliveira, AC Monteleone-Cassiano, L Tavares… - Antiviral Research, 2024 - Elsevier
Since human angiotensin-converting enzyme 2 (ACE2) serves as a primary receptor for
SARS-CoV-2, characterizing ACE2 regions that allow SARS-CoV-2 to enter human cells is …

ESCRT Protein VPS4A Is Required for the Formation of Replication Centers and Replication of Human Coronavirus 229E (HCoV-229E)

R Kumar, RK Maldonado, ND Christensen, MC Bewley… - COVID, 2024 - mdpi.com
Human coronavirus 229E (HCoV-229E) is an alpha coronavirus that infects humans and
bats. In common with all positive-strand RNA viruses, 229E infection causes rearrangements …

[HTML][HTML] SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion

J Zhang, A Kennedy, DM de Melo Jorge, L Xing… - bioRxiv, 2022 - ncbi.nlm.nih.gov
The COVID-19 pandemic is caused by SARS-CoV-2, an enveloped RNA virus. Despite
extensive investigation, the molecular mechanisms for its assembly and secretion remain …