Imbalance in the tissue microenvironment is the main obstacle to drug delivery and
distribution in the human body. Before penetrating the pathological tissue microenvironment …

Nanovaccines have gathered significant attention for their potential to elicit tumor-specific
immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines …

The success of immunotherapy approaches, such as immune checkpoint blockade and
cellular immunotherapy with genetically modified lymphocytes, has firmly embedded the …

Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function
similarly to secondary lymphoid organs (SLOs). While TLS is generally associated with an …

The induction of tumor carbonyl stress is reported to efficiently revert immune suppression in
the tumor microenvironment and enhance cancer immunotherapy. However, low oxygen …

Tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral
non-lymphoid tissues, including inflamed or cancerous tissue. Tumor-associated TLS serves …

Nanomaterials exhibit significant potential for stimulating immune responses, offering both
local and systemic modulation across a variety of diseases. The lymphoid organs, such as …

Despite the remarkable clinical success of immune checkpoint blockade (ICB) in the
treatment of cancer, the response rate to ICB therapy remains suboptimal. Recent studies …

Immunotherapy plays a vital role in cancer postoperative treatment. Strategies to increase
the variety of immune cells and their sustainable supply are essential to improve the …

Cuproptosis, a newly discovered mechanism of inducing tumor cell death, primarily relies on
the intracellular accumulation of copper ions. The utilization of Cu-based nanomaterials to …