Recent progress of bioanalytical techniques has accelerated the deep understanding of
cellular states and development of novel drugs as well as medical diagnosis. Particularly …

To reduce attrition in drug development, it is crucial to consider the development and
implementation of translational phenotypic assays as well as decipher diverse molecular …

Protein function is often regulated by posttranslational modifications (PTMs), and recent
advances in mass spectrometry have resulted in an exponential increase in PTM …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (S)
binds to angiotensin-converting enzyme 2 (ACE2) to mediate membrane fusion via two …

Protein-protein interactions play an essential role in the function of a living organism. Once
an interaction has been identified and validated it is necessary to characterize it at the …

Regulation of IFN signaling is critical in host recognition and response to pathogens while its
dysregulation underlies the pathogenesis of several chronic diseases. STimulator of IFN …

ER-plasma membrane (PM) contacts are proposed to be held together by distinct families of
tethering proteins, which in yeast include the VAP homologues Scs2/22, the extended …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that is
continuously evolving. Although its RNA-dependent RNA polymerase exhibits some …

Bioluminescence (BL) is an excellent optical readout platform that has great potential to be
utilized in various bioassays and molecular imaging. The advantages of BL-based …

Background Cognitive impairment in humans with Alzheimer's disease (AD) and in animal
models of Aβ-pathology can be ameliorated by treatments with the nuclear receptor …