HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Serotonin (5-hydroxytryptamine, 5-HT) is probably unique among the monoamines in that its
effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Serotonin (5-HT)-receptor-based mechanisms have been postulated to play a critical role in
the action of the new generation of antipsychotic drugs (APDs) that are usually referred to as …

The main class of atypical antipsychotic drugs (APDs) in current use includes the protypical
atypical APD, clozapine, as well as aripiprazole, asenapine, iloperidone, lurasidone …

Recent interest in the role of serotonin (5-HT) in antipsychotic drug action is based mainly
upon the fact that antipsychotic drugs such as clozapine, olanzapine, quetiapine …

Using radioligand binding assays and post-mortem normal human brain tissue, we obtained
equilibrium dissociation constants (Kds) for nine new antipsychotic drugs (iloperidone …

Aripiprazole, 7-{4-[4-(2, 3-dichlorophenyl)-1-piperazinyl] butyloxy}-3, 4-dihydro-2 (1H)-
quinolinone, a novel antipsychotic with partial agonist activity at dopamine D2 receptors …

Clinical depression is a common, debilitating and heterogenous disorder. Existing
treatments for depression are inadequate for a significant minority of patients and new …