The multiple mechanisms that regulate p53 activity and cell fate
A Hafner, ML Bulyk, A Jambhekar… - Nature reviews Molecular …, 2019 - nature.com
The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
Mechanisms of transcriptional regulation by p53
Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …
dozens of target genes with diverse biological functions. The activity of this master …
TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
A major constraint on the evolution of large body sizes in animals is an increased risk of
developing cancer. There is no correlation, however, between body size and cancer risk …
developing cancer. There is no correlation, however, between body size and cancer risk …
A benchmark for chromatin binding measurements in live cells
Live-cell measurement of protein binding to chromatin allows probing cellular biochemistry
in physiological conditions, which are difficult to mimic in vitro. However, different studies …
in physiological conditions, which are difficult to mimic in vitro. However, different studies …
Emerging roles for chromatin as a signal integration and storage platform
AI Badeaux, Y Shi - Nature reviews Molecular cell biology, 2013 - nature.com
Cells of a multicellular organism, all containing nearly identical genetic information, respond
to differentiation cues in variable ways. In addition, cells are plastic, able to execute their …
to differentiation cues in variable ways. In addition, cells are plastic, able to execute their …
Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain
AS Krois, HJ Dyson, PE Wright - Proceedings of the …, 2018 - National Acad Sciences
Atomic resolution characterization of the full-length p53 tetramer has been hampered by its
size and the presence of extensive intrinsically disordered regions at both the N and C …
size and the presence of extensive intrinsically disordered regions at both the N and C …
Targeting intrinsically disordered transcription factors: changing the paradigm
Increased understanding of intrinsically disordered proteins (IDPs) and protein regions has
revolutionized our view of the relationship between protein structure and function. Data now …
revolutionized our view of the relationship between protein structure and function. Data now …
The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain
O Laptenko, I Shiff, W Freed-Pastor, A Zupnick… - Molecular cell, 2015 - cell.com
DNA binding by numerous transcription factors including the p53 tumor suppressor protein
constitutes a vital early step in transcriptional activation. While the role of the central core …
constitutes a vital early step in transcriptional activation. While the role of the central core …
Melatonin: regulation of biomolecular condensates in neurodegenerative disorders
Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …
chemically distinct subcellular compartments organizing macromolecules such as proteins …
The tail that wags the dog: how the disordered C-terminal domain controls the transcriptional activities of the p53 tumor-suppressor protein
O Laptenko, DR Tong, J Manfredi, C Prives - Trends in biochemical …, 2016 - cell.com
The p53 tumor suppressor is a transcription factor (TF) that exerts antitumor functions
through its ability to regulate the expression of multiple genes. Within the p53 protein resides …
through its ability to regulate the expression of multiple genes. Within the p53 protein resides …