Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …

Diabetes mellitus (DM) and hypertension are highly prevalent worldwide health problems
and frequently associated with severe clinical complications, such as diabetic …

Neurodegenerative diseases are associated with chronic neuroinflammation in the brain,
which can result in microglial phagocytosis of live synapses and neurons that may contribute …

Abstract P2Y receptors are G protein-coupled receptors whose physiological agonists are
the nucleotides ATP, ADP, UTP, UDP and UDP-glucose. Eight P2Y receptors have been …

Purinergic signaling, mediated mainly by G protein-coupled P2Y receptors (P2YRs), is now
attracting attention as a new therapeutic target for preventing or treating cardiovascular …

The purinergic receptor P2Y 6 receptor (P2Y 6 R) is a member of the G protein-coupled
receptors (GPCR) family. P2Y 6 R is widely expressed in various cell types and plays a …

G protein-coupled receptors (GPCRs) have originally been described as a family of
receptors activated by hormones, neurotransmitters, and other mediators. However, in …

Cardiac hypertrophy, induced by neurohumoral factors, including angiotensin II and
endothelin-1, is a major predisposing factor for heart failure. These ligands can induce …

Cardiovascular disease is a major cause of morbidity and mortality worldwide. Innovative
new treatment options for this cardiovascular pandemic are urgently needed. Activation of …