The Type VII Secretion System of Staphylococcus

L Bowman, T Palmer - Annual review of microbiology, 2021 - annualreviews.org
The type VII protein secretion system (T7SS) of Staphylococcus aureus is encoded at the
ess locus. T7 substrate recognition and protein transport are mediated by EssC, a …

The enigmatic Esx proteins: looking beyond mycobacteria

M Unnikrishnan, C Constantinidou, T Palmer… - Trends in …, 2017 - cell.com
Bacteria export proteins across membranes using a range of transport machineries. Type VII
secretion systems (T7SSs), originally described in mycobacteria, are now known to be …

The NLRP6 inflammasome recognizes lipoteichoic acid and regulates gram-positive pathogen infection

H Hara, SS Seregin, D Yang, K Fukase, M Chamaillard… - Cell, 2018 - cell.com
The activator and composition of the NLRP6 inflammasome remain poorly understood. We
find that lipoteichoic acid (LTA), a molecule produced by Gram-positive bacteria, binds and …

The antibacterial type VII secretion system of Bacillus subtilis: structure and interactions of the pseudokinase YukC/EssB

M Tassinari, T Doan, M Bellinzoni, M Chabalier… - MBio, 2022 - Am Soc Microbiol
Type VIIb secretion systems (T7SSb) were recently proposed to mediate different aspects of
Firmicutes physiology, including bacterial pathogenicity and competition. However, their …

Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1

S Tiwari, R Casey, CW Goulding… - Microbiology …, 2019 - Am Soc Microbiol
Mycobacterium tuberculosis is an ancient master of the art of causing human disease. One
important weapon within its fully loaded arsenal is the type VII secretion system. M …

Extreme genetic diversity in the type VII secretion system of Listeria monocytogenes suggests a role in bacterial antagonism

K Bowran, T Palmer - Microbiology, 2021 - microbiologyresearch.org
The type VII protein secretion system (T7SS) has been characterized in members of the
phyla Actinobacteria and Firmicutes. In mycobacteria the T7SS is intimately linked with …

A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence

BL Spencer, U Tak, JC Mendonça, PE Nagao… - PLoS …, 2021 - journals.plos.org
Type VII secretion systems (T7SS) have been identified in Actinobacteria and Firmicutes and
have been shown to secrete effector proteins with functions in virulence, host toxicity, and/or …

Interbacterial competition mediated by the type VIIb secretion system

ER Boardman, T Palmer, F Alcock - Microbiology, 2023 - microbiologyresearch.org
Successful occupancy of a given niche requires the colonising bacteria to interact
extensively with the biotic and abiotic environment, including other resident microbes …

Evolving understanding of the type VII secretion system in Gram-positive bacteria

BL Spencer, KS Doran - PLoS Pathogens, 2022 - journals.plos.org
Secretion systems are commonly used by bacteria to export proteins to their extracellular
environment and are integral in bacterial niche adaptation. While most secretion systems …

MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence

J Pinheiro, J Lisboa, R Pombinho… - Nucleic Acids …, 2018 - academic.oup.com
The foodborne pathogen Listeria monocytogenes (Lm) causes invasive infection in
susceptible animals and humans. To survive and proliferate within hosts, this facultative …