Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Integrins are a family of heterodimeric receptors that bind to components of the extracellular
matrix and influence cellular processes as varied as proliferation and migration. These …

Since it has become clear that adhesion receptors are trafficked through the endosomal
pathway and that this can influence their function, much effort has been invested in obtaining …

Selective inhibition of vascular endothelial growth factor (VEGF) increases the efficacy of
chemotherapy and has beneficial effects on multiple advanced cancers, but response is …

Integrins are heterodimeric transmembrane receptors for extracellular matrix (ECM)
components and they link the intracellular actin cytoskeleton to the cellular environment …

Abstract Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling
protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here …

p53 suppresses tumorigenesis by activating a plethora of effector pathways. While most of
these operate primarily inside of cells to limit proliferation and survival of incipient cancer …

Rho guanosine triphosphatases (GTPases) are master regulators of cell shape and cell
movement [1]. The archetypal family members RhoA, Rac1, and Cdc42 arose early in …

Blood vessel expansion is driven by sprouting angiogenesis of endothelial cells, and is
essential for development, wound healing and disease. Membrane-localized vascular …

The RAS (rat sarcoma) superfamily of small GTPases is broadly subdivided into five groups:
Ras, Rho, Rab, Ran, and Arf. Rab family proteins are important in regulating signal …