Nuclear physics in particle therapy: a review

M Durante, H Paganetti - Reports on Progress in Physics, 2016 - iopscience.iop.org
Charged particle therapy has been largely driven and influenced by nuclear physics. The
increase in energy deposition density along the ion path in the body allows reducing the …

In vivo proton range verification: a review

AC Knopf, A Lomax - Physics in Medicine & Biology, 2013 - iopscience.iop.org
Protons are an interesting modality for radiotherapy because of their well defined range and
favourable depth dose characteristics. On the other hand, these same characteristics lead to …

Prompt gamma imaging with a slit camera for real-time range control in proton therapy

J Smeets, F Roellinghoff, D Prieels… - Physics in Medicine …, 2012 - iopscience.iop.org
Treatments delivered by proton therapy are affected by uncertainties on the range of the
beam within the patient, requiring medical physicists to add safety margins on the …

Proton range verification through prompt gamma-ray spectroscopy

JM Verburg, J Seco - Physics in Medicine & Biology, 2014 - iopscience.iop.org
We present an experimental study of a novel method to verify the range of proton therapy
beams. Differential cross sections were measured for 15 prompt gamma-ray lines from …

[HTML][HTML] Range verification methods in particle therapy: underlying physics and Monte Carlo modeling

AC Kraan - Frontiers in oncology, 2015 - frontiersin.org
Hadron therapy allows for highly conformal dose distributions and better sparing of organs-
at-risk, thanks to the characteristic dose deposition as function of depth. However, the quality …

Range assessment in particle therapy based on prompt γ-ray timing measurements

C Golnik, F Hueso-González, A Müller… - Physics in Medicine …, 2014 - iopscience.iop.org
Proton and ion beams open up new vistas for the curative treatment of tumors, but adequate
technologies for monitoring the compliance of dose delivery with treatment plans in real time …

Prompt gamma imaging of proton pencil beams at clinical dose rate

I Perali, A Celani, L Bombelli, C Fiorini… - Physics in Medicine …, 2014 - iopscience.iop.org
In this work, we present experimental results of a prompt gamma camera for real-time proton
beam range verification. The detection system features a pixelated Cerium doped lutetium …

Monte Carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy

M Moteabbed, S Espana… - Physics in Medicine & …, 2011 - iopscience.iop.org
The purpose of this work was to compare the clinical adaptation of prompt gamma (PG)
imaging and positron emission tomography (PET) as independent tools for non-invasive …

Energy-and time-resolved detection of prompt gamma-rays for proton range verification

JM Verburg, K Riley, T Bortfeld… - Physics in Medicine & …, 2013 - iopscience.iop.org
In this work, we present experimental results of a novel prompt gamma-ray detector for
proton beam range verification. The detection system features an actively shielded cerium …

Real-time prompt gamma monitoring in spot-scanning proton therapy using imaging through a knife-edge-shaped slit

V Bom, L Joulaeizadeh… - Physics in Medicine & …, 2011 - iopscience.iop.org
In this paper we report on Monte Carlo simulations to investigate real-time monitoring of the
track depth profile in particle therapy by measuring prompt gamma ray emissions: a high …