Recent advances in 1, 2, 4-triazolo [1, 5-a] pyrimidine chemistry

G Fischer - Advances in Heterocyclic Chemistry, 2019 - Elsevier
The review deals with the pharmaceutically and agrochemically important group of 1, 2, 4-
triazolo [1, 5-a] pyrimidines (TPs) and covers relevant literature published from about 2006 …

Synthesis, biological evaluation and DFT calculation of novel pyrazole and pyrimidine derivatives

AM Farag, AM Fahim - Journal of Molecular Structure, 2019 - Elsevier
The utility of the enaminonitriles 3a and 3b for the synthesis of the pyrazole derivatives 5a, b,
7a, b, diaminopyrimidine derivatives 9, 11, pyrazolo [1, 5-a] pyrimidines 12, 15, triazolo [4, 3 …

Synthesis of new N-phenylpyrazole derivatives with potent antimicrobial activity

AM Farag, AS Mayhoub, SE Barakat… - Bioorganic & medicinal …, 2008 - Elsevier
The versatile synthons 4-(2-bromoacetyl)-5-methyl-1-phenyl-3-phenylcarbamoyl-1H-
pyrazole (3) and 4-[(E)-3-(dimethylamino) acryloyl]-5-methyl-1-phenyl-3-phenylcarbamoyl …

Regioselective synthesis and antitumor screening of some novel N-phenylpyrazole derivatives

AM Farag, AS Mayhoub, SE Barakat… - Bioorganic & medicinal …, 2008 - Elsevier
The versatile, hitherto unreported 4-acetyl-5-methyl-1-phenyl-3-phenylcarbamoyl-1H-
pyrazole (3) was prepared via the reaction of 2-(2-phenylhydrazono)-2-chloro-N …

Synthesis and analgesic/anti-inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety

MR Shaaban, TS Saleh, AS Mayhoub… - Bioorganic & medicinal …, 2008 - Elsevier
A series of pyrazolo [1, 5-a] pyrimidine, triazolo [1, 5-a] pyrimidine, and pyrimido [1, 2-a]
benzimidazole ring systems incorporating phenylsulfonyl moiety were synthesized via the …

Mg–Al hydrotalcites as efficient catalysts for aza-Michael addition reaction: A green protocol

M Mokhtar, TS Saleh, SN Basahel - Journal of Molecular Catalysis A …, 2012 - Elsevier
Mg–Al hydrotalcite was synthesized by a co-precipitation method. We have studied the effect
of calcination temperature and hydration of the calcined phases on their catalytic activity for …

Three Component One-Pot Synthesis and Antiproliferative Activity of New [1,2,4]Triazolo[4,3-a]pyrimidines

M Ben Hassen, D Msalbi, B Jismy, F Elghali, S Aifa… - Molecules, 2023 - mdpi.com
A series of new [1, 2, 4] triazolo [4, 3-a] pyrimidine derivatives was prepared using a one-pot
three-component synthesis from 5-amino-1-phenyl-1 H-1, 2, 4-triazoles, aromatic aldehydes …

[PDF][PDF] Recent advances on the synthesis of azoles, azines and azepines fused to benzimidazole

KM Dawood, NM Elwan, BF Abdel-Wahab - Arkivoc, 2011 - academia.edu
The current review article represents a survey covering the literatures on azoles, azines and
azepines fused to the a face of a benzimidazole moiety since 1980. Synthetic routes leading …

[HTML][HTML] Ultrasound assisted synthesis of some new 1, 3, 4-thiadiazole and bi (1, 3, 4-thiadiazole) derivatives incorporating pyrazolone moiety

NM Abd EL-Rahman, TS Saleh, MF Mady - Ultrasonics sonochemistry, 2009 - Elsevier
Novel substituted 1, 3, 4-thiadiazole and bi (1, 3, 4-thiadiazole) were synthesized from
reaction of 1-methyl-5-oxo-3-phenyl-2-pyrazolin-4-thiocarbox-anilide with a series of …

Design, synthesis, and evaluation of 2-aryl-7-(3′, 4′-dialkoxyphenyl)-pyrazolo [1, 5-a] pyrimidines as novel PDE-4 inhibitors

I Kim, JH Song, CM Park, JW Jeong, HR Kim… - Bioorganic & medicinal …, 2010 - Elsevier
Described herein is design, synthesis, and biological evaluation of novel series of 2-aryl-7-
(3′, 4′-dialkoxyphenyl)-pyrazolo [1, 5-a] pyrimidines acting as inhibitors of type 4 …