Resistance to all major groups of antibiotics has arisen hand in hand with their extensive
use in medicine and animal husbandry, and macrolide antibiotics are no exception. The …

The ribosome is a large multifunctional complex composed of both RNA and proteins.
Biophysical methods are yielding low-resolution structures of the overall architecture of …

The 30S ribosomal subunit has two primary functions in protein synthesis. It discriminates
against aminoacyl transfer RNAs that do not match the codon of messenger RNA, thereby …

We describe the crystal structure of the complete Thermus thermophilus 70 S ribosome
containing bound messenger RNA and transfer RNAs (tRNAs) at 5.5 angstrom resolution …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

Crystal structures of the 30 S ribosomal subunit in complex with messenger RNA and
cognate transfer RNA in the A site, both in the presence and absence of the antibiotic …

The ribosome is a macromolecular assembly that is responsible for protein biosynthesis
following genetic instructions in all organisms. It is composed of two unequal subunits: the …

1. Introduction 3082. Electron microscopy 3112.1 Specimen preparation 3112.2 The
electron microscope 3112.3 Acceleration voltage, defocus, and the electron gun 3122.4 …

Using single-molecule fluorescence spectroscopy, time-resolved conformational changes
between fluorescently labeled tRNA have been characterized within surface-immobilized …

Structural analyses of the large and small ribosomal subunits have allowed us to think about
how they work in more detail than ever before. The mechanisms that underlie ribosomal …