Antimicrobial resistance (AMR) is a major threat to human health worldwide, and the rapid
detection and quantification of resistance, combined with antimicrobial stewardship, are key …

Background Improved genetic understanding of Mycobacterium tuberculosis (MTB)
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …

2 Global tuberculosis report 2017. Geneva: World Health Organization; 2017 (WHO/HTM/TB/
2017.23; http://www. who. int/tb/publications/global_report/en/, accessed 1 November 2017) …

Abstract Background The World Health Organization recommends drug-susceptibility testing
of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment …

The emergence of antimicrobial resistance against Mycobacterium tuberculosis, the leading
cause of mortality due to a single microbial pathogen worldwide, represents a growing threat …

Highlights•Management of tuberculosis is complicated by high levels of drug resistance in
some regions of the world.•Increasingly, molecular diagnostics are being used for resistance …

The World Health Organization's End TB Strategy prioritizes universal access to an early
diagnosis and comprehensive drug susceptibility testing (DST) for all individuals with …

Background Whole-genome sequencing (WGS) of Mycobacterium tuberculosis complex has
become an important tool in diagnosis and management of drug-resistant tuberculosis …

Rifampicin was discovered in 1965 and remains one of the most important drugs in
tuberculosis treatment that is valued for its sterilizing activity and ability to shorten treatment …

Antibiotic resistance among bacterial pathogens poses a major global health threat.
Mycobacterium tuberculosis complex (MTBC) is estimated to have the highest resistance …