New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

NA Fineberg, SR Chamberlain, AE Goudriaan… - CNS …, 2014 - cambridge.org
Impulsivity and compulsivity represent useful conceptualizations that involve dissociable
cognitive functions, which are mediated by neuroanatomically and neurochemically distinct …

Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities

RG Pertwee - … Transactions of the Royal Society B …, 2012 - royalsocietypublishing.org
Human tissues express cannabinoid CB1 and CB2 receptors that can be activated by
endogenously released 'endocannabinoids' or exogenously administered compounds in a …

Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice

HY Zhang, M Gao, QR Liu, GH Bi, X Li… - Proceedings of the …, 2014 - National Acad Sciences
Cannabinoid CB2 receptors (CB2Rs) have been recently reported to modulate brain
dopamine (DA)-related behaviors; however, the cellular mechanisms underlying these …

Brain cannabinoid receptor 2: expression, function and modulation

DJ Chen, M Gao, FF Gao, QX Su, J Wu - Acta Pharmacologica Sinica, 2017 - nature.com
Cannabis sativa (marijuana) is a fibrous flowering plant that produces an abundant variety of
molecules, some with psychoactive effects. At least 4% of the world's adult population uses …

Reviewing the role of the endocannabinoid system in the pathophysiology of depression

I Gallego-Landin, A Garcia-Baos… - Frontiers in …, 2021 - frontiersin.org
Major depressive disorder is a high-impact, debilitating disease and it is currently
considered the most prevalent mental illness. It is associated with disability, as well as …

Expression of functional cannabinoid CB2 receptor in VTA dopamine neurons in rats

HY Zhang, M Gao, H Shen, GH Bi, HJ Yang… - Addiction …, 2017 - Wiley Online Library
We have recently reported the expression of functional cannabinoid CB2 receptors (CB2Rs)
in midbrain dopamine (DA) neurons in mice. However, little is known whether CB2Rs are …

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

G Navarro, P Morales, C Rodríguez-Cueto… - Frontiers in …, 2016 - frontiersin.org
Endocannabinoids activate two types of specific G-protein-coupled receptors (GPCRs),
namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 …

Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus

Y Li, J Kim - Neuroscience, 2015 - Elsevier
In the brain, CB1 cannabinoid receptors primarily mediate the effects of cannabinoids, but
CB2 cannabinoid receptors (CB2Rs) have recently been discovered in the nervous system …

Endocannabinoid system: the direct and indirect involvement in the memory and learning processes—a short review

M Kruk-Slomka, A Dzik, B Budzynska, G Biala - Molecular neurobiology, 2017 - Springer
The endocannabinoid system via cannabinoid (CB: CB1 and CB2) receptors and their
endogenous ligands is directly and indirectly involved in many physiological functions …

Cannabinoid use and self-injurious behaviours: A systematic review and meta-analysis

A Escelsior, MB Murri, GP Corsini, G Serafini… - Journal of affective …, 2021 - Elsevier
Background The increasing availability of high-potency cannabis-derived compounds and
the use of synthetic cannabinoids may be responsible for severe side effects like cognitive …