Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy
Oncogenesis is associated with intestinal dysbiosis, and stool shotgun metagenomic
sequencing in individuals with this condition might constitute a non-invasive approach for …
sequencing in individuals with this condition might constitute a non-invasive approach for …
Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science
Cancer is generally regarded as a localised disease, with the well-established role of the
tumour microenvironment. However, the realm of cancer goes beyond the tumour …
tumour microenvironment. However, the realm of cancer goes beyond the tumour …
A core microbiome signature as an indicator of health
The gut microbiota is crucial for human health, functioning as a complex adaptive system
akin to a vital organ. To identify core health-relevant gut microbes, we followed the systems …
akin to a vital organ. To identify core health-relevant gut microbes, we followed the systems …
[HTML][HTML] Population-level metagenomics uncovers distinct effects of multiple medications on the human gut microbiome
N Nagata, S Nishijima, T Miyoshi-Akiyama, Y Kojima… - Gastroenterology, 2022 - Elsevier
Background & aims Medication is a major determinant of human gut microbiome structure,
and its overuse increases the risks of morbidity and mortality. However, effects of certain …
and its overuse increases the risks of morbidity and mortality. However, effects of certain …
Depletion of butyrate-producing microbes of the Firmicutes predicts nonresponse to FMT therapy in patients with recurrent Clostridium difficile infection
H Tian, J Cui, C Ye, J Zhao, B Yang, Y Xu, S Ji… - Gut …, 2023 - Taylor & Francis
Approximately 10% of individuals diagnosed with Clostridium difficile infection (CDI) show
the resistance to fecal microbiota transplantation (FMT), with the underlying mechanisms …
the resistance to fecal microbiota transplantation (FMT), with the underlying mechanisms …
Barriers and opportunities in pancreatic cancer immunotherapy
Y Ju, D Xu, M Liao, Y Sun, W Bao, F Yao… - NPJ Precision …, 2024 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) presents a fatal clinical challenge characterized
by a dismal 5-year overall survival rate, primarily due to the lack of early diagnosis and …
by a dismal 5-year overall survival rate, primarily due to the lack of early diagnosis and …
Emerging mechanisms and promising approaches in pancreatic cancer metabolism
H Wu, M Fu, M Wu, Z Cao, Q Zhang, Z Liu - Cell Death & Disease, 2024 - nature.com
Pancreatic cancer is an aggressive cancer with a poor prognosis. Metabolic abnormalities
are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to …
are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to …
Predicting personalized responses to dietary fiber interventions: opportunities for modulation of the gut microbiome to improve health
Inadequate dietary fiber consumption has become common across industrialized nations,
accompanied by changes in gut microbial composition and a dramatic increase in chronic …
accompanied by changes in gut microbial composition and a dramatic increase in chronic …
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations
The microbiota in individual habitats differ in both relative composition and absolute
abundance. While sequencing approaches determine the relative abundances of taxa and …
abundance. While sequencing approaches determine the relative abundances of taxa and …
Microbiome as a biomarker and therapeutic target in pancreatic cancer
G Pourali, D Kazemi, AS Chadeganipour… - BMC microbiology, 2024 - Springer
Studying the effects of the microbiome on the development of different types of cancer has
recently received increasing research attention. In this context, the microbial content of …
recently received increasing research attention. In this context, the microbial content of …