Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …

Astrocytes support neuronal function by providing essential structural and nutritional
support, neurotransmitter trafficking and recycling and may also contribute to brain …

Systemic arterial hypertension has been previously suggested to develop as a
compensatory condition when central nervous perfusion/oxygenation is compromised …

Short-term and long-term blood pressure (BP) regulation and its maintenance at levels
adequate to perfuse tissue organs involve an integrated action of multiple neural …

New Findings What is the central question of this study? This study was designed to
investigate whether the Phox2b‐expressing neurons in the retrotrapezoid nucleus are …

Astrocytes occupy a strategic position in the brain where they can act as an interface
between neurones and blood vessels, and neurones and the cerebro-spinal fluid. This …

Breathing is regulated by a host of arousal and sleep-wake state-dependent
neuromodulators to maintain respiratory homeostasis. Modulators such as acetylcholine …

Rapid phosphoester hydrolysis of endogenous purine and pyrimidine nucleotides has
challenged the characterization of the role of P2 receptors in physiology and pathology …

Hypertension is the leading cause of morbidity and mortality globally among all
cardiovascular diseases. Purinergic signalling plays a crucial role in hypertension through …

Key points Several brain regions are thought to sense changes in tissue CO2/H+ to regulate
breathing (ie central chemoreceptors) including the nucleus of the solitary tract (NTS) …