The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …

IL-6 is a pleiotropic cytokine with broad-ranging effects within the integrated immune
response. One of the roles of IL-6 is to support immunocompetence, defined as the ability of …

Abstract The effects of Jak Stat signaling and the persistent activation of Stat3 and Stat5 on
tumor cell survival, proliferation and invasion have made the Jak Stat pathway a favorite …

The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and
involution to prepare the gland for subsequent lactation. The mammary epithelial cells …

Aryl hydrocarbon receptor (AhR), an evolutionary conserved transcription factor, is a
pleiotropic signal transductor. Thanks to its promiscuous ligand binding domain, during the …

Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) have
been shown to function downstream of several peptide hormones and cytokines that are …

Cytokines are required for normal growth and development of the mammary gland and TGF-
β prominently represents an established effector of apoptosis, eg, during involution of the …

Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine
signaling, tissue homeostasis, and cancer development. Using a breast cancer model that …

Malignant tumors pose a great challenge to human health, which has led to many studies
increasingly elucidating the tumorigenic process. Cancer Stem Cells (CSCs) have profound …

Impaired wound healing is commonly encountered in patients with diabetes mellitus, which
may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a …