The use of small animal models in basic and preclinical sciences constitutes an integral part
of testing new pharmaceutical agents prior to commercial translation to clinical practice …

Breast cancer has become a common tumor worldwide which seriously endangers people's
health. Early diagnosis and treatment are particularly urgent in order to reduce the onset …

To develop an indocyanine green (ICG) tracer with slower clearance kinetics, we explored
ICG-encapsulating liposomes (Lip) in three different formulations: untargeted (Lip/ICG) …

Tumor hypoxia is a major indicator of treatment resistance to chemotherapeutic drugs, and
fluorescence optical tomography has tremendous potential to provide clinically useful …

We have developed a novel nitroimidazole indocyanine dye conjugate for tumor-targeted
hypoxia fluorescence tomography. The hypoxia probe has been evaluated in vitro using …

Standard small molecule and nanoparticulate chemotherapies are used for cancer
treatment; however, their effectiveness remains highly variable. One reason for this variable …

We have prepared a series of indocyanine green dicarboxylic acid derivatives (9a, b, 4, 10,
13) with modified polyene linkers in an attempt to increase the structural rigidity of the …

Tumor angiogenesis, the formation of new blood vessels within the tumor microenvironment,
is considered a hallmark of cancer progression and represents a crucial target for …

Tumor functional and molecular imaging has significantly contributed to cancer preclinical
research and clinical applications. Among typical imaging modalities, ultrasonic and optical …

We report the tomographic imaging of a photodynamic therapy (PDT) photosensitizer, 2-(1-
hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) in vivo with time-domain fluorescence …