Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become
a research hotspot and already show immense potential to become pharmaceutically …

Innate immunity is the front line of self-defense against infectious non-self in vertebrates and
invertebrates. The innate immune system is mediated by germ-line encoding pattern …

The vertebrate protein STING, an intracellular sensor of cyclic dinucleotides, is critical to the
innate immune response and the induction of type I interferon during pathogenic infection …

The fruit fly Drosophila melanogaster is a good model to unravel the molecular mechanisms
of innate immunity and has led to some important discoveries about the sensing and …

Virus transmission and spread by arthropods is a major economic and public health
concern. The ongoing dissemination of arthropod-borne viruses by blood-feeding insects is …

The marine mussel Mytilus edulis and its closely related sister species are distributed world-
wide and play an important role in coastal ecology and economy. The diversification in …

Background Lying downstream of a myriad of cytokine receptors, the Janus kinase (JAK)–
Signal transducer and activator of transcription (STAT) pathway is pivotal for the …

The fruit fly Drosophila melanogaster combats microbial infection by producing a battery of
effector peptides that are secreted into the haemolymph. Technical difficulties prevented the …

The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly
revolutionized this research field and made it possible to carry out functional studies on …

Recognition of invading microbes as non-self is the first step of immune responses. In
insects, peptidoglycan recognition proteins (PGRPs) detect peptidoglycans (PGs) of …