Understanding and overcoming resistance to PARP inhibitors in cancer therapy
Developing novel targeted anticancer therapies is a major goal of current research. The use
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
RX Huang, PK Zhou - Signal transduction and targeted therapy, 2020 - nature.com
Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …
tumors. However, the radioresistance of cancer cells is still a major limitation for …
DNA double-strand break repair-pathway choice in somatic mammalian cells
The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining
genomic stability. However, if deployed in an inappropriate cellular context, these same …
genomic stability. However, if deployed in an inappropriate cellular context, these same …
Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments
The DNA damage response (DDR) generates transient repair compartments to concentrate
repair proteins and activate signaling factors. The physicochemical properties of these …
repair proteins and activate signaling factors. The physicochemical properties of these …
Biomarker-guided development of DNA repair inhibitors
JM Cleary, AJ Aguirre, GI Shapiro, AD D'Andrea - Molecular cell, 2020 - cell.com
Anti-cancer drugs targeting the DNA damage response (DDR) exploit genetic or functional
defects in this pathway through synthetic lethal mechanisms. For example, defects in …
defects in this pathway through synthetic lethal mechanisms. For example, defects in …
How cells ensure correct repair of DNA double-strand breaks
J Her, SF Bunting - Journal of Biological Chemistry, 2018 - ASBMB
DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause
senescence or cell death. Homologous recombination (HR) and nonhomologous end …
senescence or cell death. Homologous recombination (HR) and nonhomologous end …
53BP1: a DSB escort
Z Mirman, T de Lange - Genes & development, 2020 - genesdev.cshlp.org
Abstract 53BP1 is an enigmatic DNA damage response factor that gained prominence
because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient …
because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient …
Regulation of repair pathway choice at two-ended DNA double-strand breaks
A Shibata - … Research/Fundamental and Molecular Mechanisms of …, 2017 - Elsevier
A DNA double-strand break (DSB) is considered to be a critical DNA lesion because its
misrepair can cause severe mutations, such as deletions or chromosomal translocations …
misrepair can cause severe mutations, such as deletions or chromosomal translocations …
Immediate-early, early, and late responses to DNA double stranded breaks
SR Kieffer, NF Lowndes - Frontiers in Genetics, 2022 - frontiersin.org
Loss or rearrangement of genetic information can result from incorrect responses to DNA
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …
Resistance to DNA repair inhibitors in cancer
The DNA damage response (DDR) represents a complex network of proteins which detect
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …