Cellular senescence, classically defined as stable cell cycle arrest, is implicated in biological
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …

Cardiovascular regenerative therapies are pursued on both basic and translational levels.
Although efficacy and value of cell therapy for myocardial regeneration can be debated …

Aging leads to increased cellular senescence and is associated with decreased potency of
tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac …

Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular
level, ageing entails decreased replicative capacity and dysregulation of cellular processes …

Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and
possess the potential to differentiate in all cell types of the organ in which they operate. Adult …

Extracellular vesicles (EVs) from stem cells have shown significant therapeutic potential to
repair injured cardiac tissues and regulate pathological fibrosis. However, scalable …

The organization of an integrated coronary vasculature requires the specification of
immature endothelial cells (ECs) into arterial and venous fates based on their localization …

Melatonin, a hormone secreted by the pineal gland, possesses multiple biological activities
such as antitumor, antioxidant, and anti‐ischemia. C‐kit+ cardiac progenitor cells (CPC s) …

Aging is considered as inevitable changes at different levels of genome, cell, and organism.
From the accumulation of DNA damages to imperfect protein homeostasis, altered cellular …

Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) are at the center of new
cell-based therapies for cardiac disease, but may also serve as a useful in vitro model for …