In recent years, brain diseases have seriously threatened human health due to their high
morbidity and mortality. Achieving efficient drug delivery to provide satisfactory therapeutic …

Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to
the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical …

The blood–brain barrier (BBB) is composed of brain endothelial cells, pericytes, and
astrocytes, which build a tight cellular barrier. Therapeutic (macro) molecules are not able to …

Introduction: Current therapies of neurodegenerative or neurometabolic diseases are, to a
large extent, hampered by the inability of drugs to cross the blood-brain barrier (BBB). This …

Ischemic stroke is a vascular central nervous system (CNS) disease that leads a disability
and death. Thrombolysis and neuroprotection are the primary treatment strategies of …

Given that albumin has important roles in human body, it can be used in the field of medicine
and disease treatment. In recent years, albumin is used as a carries in disease diagnosis …

After decades of research, nanotechnology has been used in a broad array of biomedical
products including medical devices, drug products, drug substances, and pharmaceutical …

Nerve growth factor (NGF) was the first-discovered member of the neurotrophin family, a
class of bioactive molecules which exerts powerful biological effects on the CNS and other …

Targeted delivery of doxorubicin still poses a challenge with regards to the quantities
reaching the target site as well as the specificity of the uptake. In the present approach, two …

A growing number of nanomedicines entered the clinical trials and improved our
understanding of the in vivo responses expected in humans. The in vitro drug release …