Treatment of advanced (metastatic) non-small-cell lung cancer (NSCLC) is currently mainly
based on immunotherapy with antibodies against PD-1 or PD-L1, alone, or in combination …

Organelles form tight connections through membrane contact sites, thereby cooperating to
regulate homeostasis and cell function. Among them, the contact between endoplasmic …

Simple Summary Due to the lack of selectivity and the severe side-effects, cytostatics are the
drugs of the present but not of the future and consequently new anticancer strategies must …

Background Tumor microenvironment (TME) plays a vital role in the development of
hepatocellular carcinoma (HCC). Mounting evidence indicates that peripheral nerves could …

Peripheral nerves have emerged as the important components in tumor microenvironment
(TME), which could activate hepatic stellate cells (HSCs) by secreting substance P (SP) …

Ions are the cornerstones of various biological functions and have been widely used for
tumor therapy, called ion interference therapy (IIT). Calcium ion (Ca 2+) is one of the most …

Oxidative stress which refers to redox imbalance with increased generation of reactive
oxygen species (ROS) has been associated with the pathophysiology of diverse disease …

As the indispensable second cellular messenger, calcium signaling is involved in the
regulation of almost all physiological processes by activating specific target proteins. The …

Ovarian cancer is a common gynecologic malignancy with a high fatality rate. Intraperitoneal
chemotherapy has been proved as an efficient clinical treatment for disseminated ovarian …

Although there is no doubt regarding the involvement of oxidative stress in the development
of glioblastoma, many questions remained unanswered about signaling cascades that …