Studies of neurodegenerative diseases using Drosophila and the development of novel approaches for their analysis

Y Nitta, A Sugie - Fly, 2022 - Taylor & Francis
The use of Drosophila in neurodegenerative disease research has contributed to the
identification of modifier genes for the pathology. The basis for neurodegenerative disease …

Homeostatic roles of the proteostasis network in dendrites

EN Lottes, DN Cox - Frontiers in Cellular Neuroscience, 2020 - frontiersin.org
Cellular protein homeostasis, or proteostasis, is indispensable to the survival and function of
all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally …

The TRP channels Pkd2, NompC, and Trpm act in cold-sensing neurons to mediate unique aversive behaviors to noxious cold in Drosophila

HN Turner, K Armengol, AA Patel, NJ Himmel… - Current biology, 2016 - cell.com
The basic mechanisms underlying noxious cold perception are not well understood. We
developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing …

RAB-10-dependent membrane transport is required for dendrite arborization

W Zou, S Yadav, L DeVault, YN Jan… - PLoS genetics, 2015 - journals.plos.org
Formation of elaborately branched dendrites is necessary for the proper input and
connectivity of many sensory neurons. Previous studies have revealed that dendritic growth …

The histone demethylase KDM5 activates gene expression by recognizing chromatin context through its PHD reader motif

X Liu, J Secombe - Cell reports, 2015 - cell.com
KDM5 family proteins are critically important transcriptional regulators whose physiological
functions in the context of a whole animal remain largely unknown. Using genome-wide …

Deterministic and stochastic rules of branching govern dendrite morphogenesis of sensory neurons

A Palavalli, N Tizón-Escamilla, JF Rupprecht, T Lecuit - Current Biology, 2021 - cell.com
Dendrite morphology is necessary for the correct integration of inputs that neurons receive.
The branching mechanisms allowing neurons to acquire their type-specific morphology …

A butterfly pan-genome reveals that a large amount of structural variation underlies the evolution of chromatin accessibility

AA Ruggieri, L Livraghi, JJ Lewis, E Evans… - Genome …, 2022 - genome.cshlp.org
Despite insertions and deletions being the most common structural variants (SVs) found
across genomes, not much is known about how much these SVs vary within populations and …

Cell-autonomous control of neuronal dendrite expansion via the fatty acid synthesis regulator SREBP

AB Ziegler, C Thiele, F Tenedini, M Richard… - Cell reports, 2017 - cell.com
During differentiation, neurons require a high lipid supply for membrane formation as they
elaborate complex dendritic morphologies. While glia-derived lipids support neuronal …

The genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel

JB Wang, HL Lu, RJ St. Leger - PLoS pathogens, 2017 - journals.plos.org
Individuals vary extensively in the way they respond to disease but the genetic basis of this
variation is not fully understood. We found substantial individual variation in resistance and …

Persistent epigenetic reprogramming of sweet taste by diet

A Vaziri, M Khabiri, BT Genaw, CE May… - Science …, 2020 - science.org
Diets rich in sugar, salt, and fat alter taste perception and food preference, contributing to
obesity and metabolic disorders, but the molecular mechanisms through which this occurs …