Studies of neurodegenerative diseases using Drosophila and the development of novel approaches for their analysis
The use of Drosophila in neurodegenerative disease research has contributed to the
identification of modifier genes for the pathology. The basis for neurodegenerative disease …
identification of modifier genes for the pathology. The basis for neurodegenerative disease …
Homeostatic roles of the proteostasis network in dendrites
Cellular protein homeostasis, or proteostasis, is indispensable to the survival and function of
all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally …
all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally …
The TRP channels Pkd2, NompC, and Trpm act in cold-sensing neurons to mediate unique aversive behaviors to noxious cold in Drosophila
The basic mechanisms underlying noxious cold perception are not well understood. We
developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing …
developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing …
RAB-10-dependent membrane transport is required for dendrite arborization
Formation of elaborately branched dendrites is necessary for the proper input and
connectivity of many sensory neurons. Previous studies have revealed that dendritic growth …
connectivity of many sensory neurons. Previous studies have revealed that dendritic growth …
The histone demethylase KDM5 activates gene expression by recognizing chromatin context through its PHD reader motif
KDM5 family proteins are critically important transcriptional regulators whose physiological
functions in the context of a whole animal remain largely unknown. Using genome-wide …
functions in the context of a whole animal remain largely unknown. Using genome-wide …
Deterministic and stochastic rules of branching govern dendrite morphogenesis of sensory neurons
Dendrite morphology is necessary for the correct integration of inputs that neurons receive.
The branching mechanisms allowing neurons to acquire their type-specific morphology …
The branching mechanisms allowing neurons to acquire their type-specific morphology …
A butterfly pan-genome reveals that a large amount of structural variation underlies the evolution of chromatin accessibility
Despite insertions and deletions being the most common structural variants (SVs) found
across genomes, not much is known about how much these SVs vary within populations and …
across genomes, not much is known about how much these SVs vary within populations and …
Cell-autonomous control of neuronal dendrite expansion via the fatty acid synthesis regulator SREBP
AB Ziegler, C Thiele, F Tenedini, M Richard… - Cell reports, 2017 - cell.com
During differentiation, neurons require a high lipid supply for membrane formation as they
elaborate complex dendritic morphologies. While glia-derived lipids support neuronal …
elaborate complex dendritic morphologies. While glia-derived lipids support neuronal …
The genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel
JB Wang, HL Lu, RJ St. Leger - PLoS pathogens, 2017 - journals.plos.org
Individuals vary extensively in the way they respond to disease but the genetic basis of this
variation is not fully understood. We found substantial individual variation in resistance and …
variation is not fully understood. We found substantial individual variation in resistance and …
Persistent epigenetic reprogramming of sweet taste by diet
Diets rich in sugar, salt, and fat alter taste perception and food preference, contributing to
obesity and metabolic disorders, but the molecular mechanisms through which this occurs …
obesity and metabolic disorders, but the molecular mechanisms through which this occurs …