Biochemical reactions are intrinsically stochastic, leading to variation in the production of
mRNAs and proteins within cells. In the scientific literature, this source of variation is typically …

Bacterial growth presents many beautiful phenomena that pose new theoretical challenges
to statistical physicists, and are also amenable to laboratory experimentation. This review …

Live-cell imaging has opened an exciting window into the role cellular heterogeneity plays
in dynamic, living systems. A major critical challenge for this class of experiments is the …

Persisters represent a small subpopulation of non-or slow-growing bacterial cells that are
tolerant to killing by antibiotics. Despite their prominent role in the recalcitrance of chronic …

Evolutionarily divergent bacteria share a common phenomenological strategy for cell-size
homeostasis under steady-state conditions. In the presence of inherent physiological …

The FANTOM5 project investigates transcription initiation activities in more than 1,000
human and mouse primary cells, cell lines and tissues using CAGE. Based on manual …

Biosynthesis enables renewable production of manifold compounds, yet often biosynthetic
performance must be improved for it to be economically feasible. Nongenetic, cell-to-cell …

Cellular reprogramming by only small molecules holds enormous potentials for regenerative
medicine. However, chemical reprogramming remains a slow process and labour intensive …

While complex dynamic biological networks control gene expression in all living organisms,
the forward engineering of comparable synthetic networks remains challenging. The current …

Despite decades of research, how mammalian cell size is controlled remains unclear
because of the difficulty of directly measuring growth at the single-cell level. Here we report …